2. Gene
  3. Orai1 - ORAI calcium release-activated calcium modulator 1 Gene

Orai1 - ORAI calcium release-activated calcium modulator 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as RGD1311873

Gene ID: 304496 | Gene type: protein coding

About Orai1

Summary

Enables store-operated Calcium Channel activity. Involved in store-operated calcium entry. Located in growth cone and plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 9 and tubular aggregate myopathy 2. Orthologous to human ORAI1 (ORAI calcium release-activated calcium modulator 1). [provided by Alliance of Genome Resources, Apr 2022]

Orai1 Products(1)

mRNA Protein Name
NM_001013982.1 NP_001014004.1 calcium release-activated calcium channel protein 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
23711249 RGD
enables store-operated calcium channel activity IMP
IMP: Inferred from mutant phenotype
21389210 RGD
Biological Process GO Annotation Evidence Reference Source
involved in store-operated calcium entry IMP
IMP: Inferred from mutant phenotype
21389210 RGD
Cellular Component GO Annotation Evidence Reference Source
located in growth cone IDA
IDA: Inferred from direct assay
22712562 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

calcium release-activated calcium channel protein 1

calcium release-activated calcium modulator 1

protein orai-1

transmembrane protein 142A

Orai1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Orai1 Q5M848 Stim2 Rattus norvegicus D4A5X1
Anti Bait CoIP
23711249
Intra
Orai1 Q5M848 Stim2 Rattus norvegicus D4A5X1
PLA
23711249
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-101942 Zegocractin Inhibitor 99.96% Phase 2
Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-19408 Pyr10 Inhibitor 99.95% Unkown
HY-103310 MRS1845 Inhibitor 99.46% Unkown
HY-113618B RO2959 monohydrochloride Inhibitor 98.19% Unkown
HY-12521 GSK-5498A Inhibitor 99.94% Unkown
HY-113618A RO2959 hydrochloride Inhibitor / Unkown
HY-RS17989 Orai1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-103071 GSK-5503A Inhibitor / Unkown
HY-RS09822 ORAI1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24460 Orai1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990478 Anti-Orai1 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Orai1 NCBI NCBI:84876