Pias1 - protein inhibitor of activated STAT, 1 Gene

Rattus norvegicus

Gene ID: 300772 | Gene type: protein coding

About Pias1

Summary

Enables SUMO transferase activity; protein C-terminus binding activity; and protein domain specific binding activity. Involved in several processes, including G1/S transition of mitotic cell cycle; positive regulation of nitrogen compound metabolic process; and visual learning. Located in nucleus. Biomarker of focal segmental glomerulosclerosis. Orthologous to human PIAS1 (protein inhibitor of activated STAT 1). [provided by Alliance of Genome Resources, Apr 2022]

Pias1 Products(1)

mRNA	Protein	Name
NM_001106829.3	NP_001100299.3	E3 SUMO-protein ligase PIAS1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables SUMO transferase activity	EXP EXP: Inferred from Experiment	23118920	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	14500712	RGD
enables protein domain specific binding	IDA IDA: Inferred from direct assay	22406621	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	19198660	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	20818504	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	20818504	RGD
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	16135793	RGD
involved in positive regulation of protein sumoylation	IMP IMP: Inferred from mutant phenotype	25031400	RGD
involved in positive regulation of smooth muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	16135793	RGD
involved in protein-DNA complex assembly	IMP IMP: Inferred from mutant phenotype	16135793	RGD
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	12799075	RGD
involved in visual learning	IMP IMP: Inferred from mutant phenotype	25031400	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

E3 SUMO-protein ligase PIAS1

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W062696	BC-1382	Inhibitor	99.53%	Unkown
HY-RS10473	PIAS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20081	Pias1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26584	Pias1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pias1	NCBI	NCBI:8554

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