Rrm2b - ribonucleotide reductase regulatory TP53 inducible subunit M2B Gene

Rattus norvegicus

Gene ID: 299976 | Gene type: protein coding

About Rrm2b

Summary

Predicted to enable identical protein binding activity and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in response to amine. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5; mitochondrial DNA depletion syndrome 8a; and mitochondrial DNA depletion syndrome 8b. Orthologous to human RRM2B (ribonucleotide reductase regulatory TP53 inducible subunit M2B). [provided by Alliance of Genome Resources, Apr 2022]

Rrm2b Products(1)

mRNA	Protein	Name
NM_001130543.1	NP_001124015.1	ribonucleoside-diphosphate reductase subunit M2 B

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in response to amine	IEP IEP: Inferred from expression pattern	14587038	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ribonucleoside-diphosphate reductase subunit M2 B

ribonucleotide reductase M2 B (TP53 inducible)

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12287	RRM2B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21746	Rrm2b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28263	Rrm2b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rrm2b	NCBI	NCBI:50484

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