Lrp1 - LDL receptor related protein 1 Gene

Rattus norvegicus

Also known as LRP-1

Gene ID: 299858 | Gene type: protein coding

About Lrp1

Summary

Enables coreceptor activity and protease binding activity. Involved in several processes, including positive regulation of transport; regulation of cytosolic calcium ion concentration; and regulation of neuron projection development. Located in several cellular components, including axonal growth cone; cytoplasmic vesicle; and neuronal cell body. Used to study diabetes mellitus. Biomarker of Alzheimer's disease; prostate carcinoma in situ; and sciatic neuropathy. Human ortholog(s) of this gene implicated in Alzheimer's disease; keratosis pilaris atrophicans; myocardial infarction; and sciatic neuropathy. Orthologous to human LRP1 (LDL receptor related protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Lrp1 Products(1)

mRNA	Protein	Name
NM_001130490.1	NP_001123962.1	prolow-density lipoprotein receptor-related protein 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables coreceptor activity	IDA IDA: Inferred from direct assay	18321860	RGD
enables protease binding	IPI IPI: Inferred from physical interaction	10514495	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12153398	RGD
enables protein serine/threonine kinase binding	IPI IPI: Inferred from physical interaction	15272003	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular lipid catabolic process	IMP IMP: Inferred from mutant phenotype	26506094	RGD
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	8930375	RGD
involved in chemoattraction of axon	IMP IMP: Inferred from mutant phenotype	26598525	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17065459	RGD
involved in negative regulation of cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	20197276	RGD
involved in negative regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	22674573	RGD
involved in negative regulation of focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	20197276	RGD
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	24086544	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	17314289	RGD
involved in negative regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	23132925	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	24865476	RGD
involved in positive regulation of Schwann cell migration	IMP IMP: Inferred from mutant phenotype	20197276	RGD
involved in positive regulation of axon extension	IMP IMP: Inferred from mutant phenotype	21040802	RGD
involved in positive regulation of axon extension involved in regeneration	IDA IDA: Inferred from direct assay	23867460	RGD
involved in positive regulation of chemokine (C-X-C motif) ligand 2 production	IMP IMP: Inferred from mutant phenotype	21290408	RGD
involved in positive regulation of cholesterol import	IMP IMP: Inferred from mutant phenotype	22454363	RGD
involved in positive regulation of collateral sprouting of injured axon	IDA IDA: Inferred from direct assay	23867460	RGD
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	18321860	RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	24865476	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	24086544	RGD
involved in positive regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	19299462	RGD
involved in positive regulation of protein transport	IMP IMP: Inferred from mutant phenotype	11100124	RGD
involved in positive regulation of vascular associated smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	20940000	RGD
involved in receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	8626514	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical part of cell	IDA IDA: Inferred from direct assay	20488202	RGD
located in axonal growth cone	IDA IDA: Inferred from direct assay	26598525	RGD
located in clathrin-coated vesicle	IDA IDA: Inferred from direct assay	16190982	RGD
located in dendrite	IDA IDA: Inferred from direct assay	9046007	RGD
located in endosome	IDA IDA: Inferred from direct assay	14701798	RGD
located in insulin-responsive compartment	IDA IDA: Inferred from direct assay	19864425	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	9046007	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

prolow-density lipoprotein receptor-related protein 1

low density lipoprotein receptor-related protein 1

low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P4073	ANG1005		98.83%	Phase 3

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1363B	β-Amyloid (1-42), human, HFIP-treated		99.89%	Unkown
HY-172698	DSPE-PEG1000-ANG		/	Unkown
HY-172699	DSPE-PEG2000-ANG		/	Unkown
HY-172699A	DSPE-PEG3400-ANG		/	Unkown
HY-172700	DSPE-PEG5000-ANG		/	Unkown
HY-P10502	L57		/	Unkown
HY-P10911	IETP2	Ligand	/	Unkown
HY-RS07792	LRP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07796	LRP1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-165426	HB-230		/	Unkown
HY-RS16670	Lrp1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23105	Lrp1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lrp1	NCBI	NCBI:4035
Canis lupus familiaris	Lrp1	NCBI
Mus musculus	Lrp1	NCBI	NCBI:16971

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