Lrp1 - low density lipoprotein receptor-related protein 1 Gene

Mus musculus

Also known as Lrp; A2mr; CD91; b2b1554Clo

Gene ID: 16971 | Gene type: protein coding

About Lrp1

Summary

Enables calcium ion binding activity; cargo receptor activity; and signaling receptor binding activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and positive regulation of transport. Acts upstream of or within several processes, including apoptotic cell clearance; Cholesterol metabolic process; and heart development. Located in external side of plasma membrane. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and respiratory system. Used to study Alzheimer's disease; cardiomyopathy; congenital diaphragmatic hernia; gastroschisis; and omphalocele. Human ortholog(s) of this gene implicated in Alzheimer's disease; keratosis pilaris atrophicans; myocardial infarction; and sciatic neuropathy. Orthologous to human LRP1 (LDL receptor related protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Lrp1 Products(1)

mRNA	Protein	Name
NM_008512.2	NP_032538.2	prolow-density lipoprotein receptor-related protein 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	3266596	MGI
enables cargo receptor activity	IMP IMP: Inferred from mutant phenotype	21289173	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10772929	MGI
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	31023188	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in amyloid-beta clearance	IMP IMP: Inferred from mutant phenotype	19098903	MGI
involved in amyloid-beta clearance by cellular catabolic process	IDA IDA: Inferred from direct assay	21289173	MGI
involved in amyloid-beta clearance by cellular catabolic process	IGI IGI: Inferred from genetic interaction	24305823	MGI
involved in amyloid-beta clearance by cellular catabolic process	IMP IMP: Inferred from mutant phenotype	23152628	MGI
involved in amyloid-beta clearance by transcytosis	IDA IDA: Inferred from direct assay	20630619	MGI
involved in aorta morphogenesis	IMP IMP: Inferred from mutant phenotype	19742316	MGI
acts upstream of or within apoptotic cell clearance	IMP IMP: Inferred from mutant phenotype	15647754	MGI
involved in astrocyte activation involved in immune response	IGI IGI: Inferred from genetic interaction	23152628	MGI
acts upstream of or within cardiac septum development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
involved in cellular response to amyloid-beta	IGI IGI: Inferred from genetic interaction	23152628	MGI
acts upstream of or within cholesterol metabolic process	IMP IMP: Inferred from mutant phenotype	17920016	MGI
acts upstream of or within coronary vasculature development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
involved in enzyme-linked receptor protein signaling pathway	IMP IMP: Inferred from mutant phenotype	31023188	MGI
involved in lysosomal transport	IDA IDA: Inferred from direct assay	26370502	MGI
involved in negative regulation of SMAD protein signal transduction	IMP IMP: Inferred from mutant phenotype	31023188	MGI
acts upstream of or within negative regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	16207730	MGI
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	31023188	MGI
involved in negative regulation of platelet-derived growth factor receptor-beta signaling pathway	IMP IMP: Inferred from mutant phenotype	19742316	MGI
involved in negative regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	19742316	MGI
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IGI IGI: Inferred from genetic interaction	31023188	MGI
involved in positive regulation of amyloid-beta clearance	IMP IMP: Inferred from mutant phenotype	26619118	MGI
involved in positive regulation of cholesterol efflux	IMP IMP: Inferred from mutant phenotype	19718435	MGI
involved in positive regulation of lipid transport	IMP IMP: Inferred from mutant phenotype	19718435	MGI
involved in positive regulation of transcytosis	IMP IMP: Inferred from mutant phenotype	26619118	MGI
acts upstream of or within receptor-mediated endocytosis	IDA IDA: Inferred from direct assay	21795536	MGI
involved in receptor-mediated endocytosis	IGI IGI: Inferred from genetic interaction	21289173	MGI
involved in receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	21289173	MGI
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	19742316	MGI
involved in regulation of cholesterol transport	IMP IMP: Inferred from mutant phenotype	19718435	MGI
involved in regulation of phospholipase A2 activity	IMP IMP: Inferred from mutant phenotype	19718435	MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization	EXP EXP: Inferred from Experiment	23760271	MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization	IDA IDA: Inferred from direct assay	23760271	MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization	IMP IMP: Inferred from mutant phenotype	23760271	MGI
involved in regulation of pulmonary blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	31023188	MGI
involved in transport across blood-brain barrier	IMP IMP: Inferred from mutant phenotype	20630619	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	19299737	MGI
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	23760271	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	23760271	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	23760271	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	23760271	MGI
located in membrane	IDA IDA: Inferred from direct assay	15082773	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	3266596	MGI
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	23760271	MGI
is active in postsynaptic density membrane	IEP IEP: Inferred from expression pattern	23760271	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

prolow-density lipoprotein receptor-related protein 1

LRP-1	alpha 2-macroglobulin receptor
lipoprotein receptor-related protein

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P4073	ANG1005		98.83%	Phase 3

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1363B	β-Amyloid (1-42), human, HFIP-treated		99.89%	Unkown
HY-172698	DSPE-PEG1000-ANG		/	Unkown
HY-172699	DSPE-PEG2000-ANG		/	Unkown
HY-172699A	DSPE-PEG3400-ANG		/	Unkown
HY-172700	DSPE-PEG5000-ANG		/	Unkown
HY-P10502	L57		/	Unkown
HY-P10911	IETP2	Ligand	/	Unkown
HY-RS07792	LRP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07796	LRP1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-165426	HB-230		/	Unkown
HY-RS16670	Lrp1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23105	Lrp1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lrp1	NCBI	NCBI:4035
Canis lupus familiaris	Lrp1	NCBI
Rattus norvegicus	Lrp1	NCBI	NCBI:299858

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