2. Gene
  3. Sdhb - succinate dehydrogenase complex iron sulfur subunit B Gene

Sdhb - succinate dehydrogenase complex iron sulfur subunit B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 298596 | Gene type: protein coding

About Sdhb

Summary

Enables Succinate Dehydrogenase (ubiquinone) activity. Involved in respiratory electron transport chain and succinate metabolic process. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; gastrointestinal stromal tumor; mitochondrial complex II deficiency; paraganglioma; and pheochromocytoma. Orthologous to human SDHB (Succinate Dehydrogenase complex iron sulfur subunit B). [provided by Alliance of Genome Resources, Apr 2022]

Sdhb Products(1)

mRNA Protein Name
NM_001100539.1 NP_001094009.1 succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables succinate dehydrogenase (quinone) activity IMP
IMP: Inferred from mutant phenotype
16520240 RGD
Biological Process GO Annotation Evidence Reference Source
involved in respiratory electron transport chain IMP
IMP: Inferred from mutant phenotype
16520240 RGD
involved in succinate metabolic process IMP
IMP: Inferred from mutant phenotype
16520240 RGD
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
16520240 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

ip

iron-sulfur subunit of complex II

succinate dehydrogenase complex, subunit B, iron sulfur (Ip)

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12593 SDHB Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-169281 Antiviral agent 61 Inhibitor / Unkown
HY-RS18259 Sdhb Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24738 Sdhb Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sdhb NCBI NCBI:6390