Ppp3r1 - protein phosphatase 3, regulatory subunit B, alpha Gene

Rattus norvegicus

Gene ID: 29748 | Gene type: protein coding

About Ppp3r1

Summary

Enables phosphoprotein Phosphatase activity. Involved in protein dephosphorylation. Predicted to be located in Schaffer collateral - CA1 synapse; parallel fiber to Purkinje cell synapse; and sarcolemma. Predicted to be part of Calcineurin complex. Predicted to be active in glutamatergic synapse. Human ortholog(s) of this gene implicated in Alzheimer's disease and dilated cardiomyopathy. Orthologous to human PPP3R1 (protein Phosphatase 3 regulatory subunit B, alpha). [provided by Alliance of Genome Resources, Apr 2022]

Ppp3r1 Products(1)

mRNA	Protein	Name
NM_017309.3	NP_059005.1	calcineurin subunit B type 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphoprotein phosphatase activity	IDA IDA: Inferred from direct assay	12135494	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15120593	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	12135494	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

calcineurin subunit B type 1

protein phosphatase 2B regulatory subunit 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11026	PPP3R1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21913	Ppp3r1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28430	Ppp3r1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ppp3r1	NCBI	NCBI:5534

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