Pdx1 - pancreatic and duodenal homeobox 1 Gene

Rattus norvegicus

Also known as Idx1; Ipf1; Stf1

Gene ID: 29535 | Gene type: protein coding

About Pdx1

Summary

Enables DNA-binding transcription factor activity; promoter-specific chromatin binding activity; and sequence-specific DNA binding activity. Contributes to DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including animal organ development; detection of glucose; and regulation of transcription, DNA-templated. Located in nucleus. Colocalizes with cytoplasm. Biomarker of acute necrotizing pancreatitis; hyperglycemia; placental insufficiency; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in cerebral infarction; hyperglycemia; maturity-onset diabetes of the young type 4; pancreatic agenesis; and type 2 diabetes mellitus. Orthologous to human PDX1 (pancreatic and duodenal homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Pdx1 Products(1)

mRNA	Protein	Name
NM_022852.4	NP_074043.4	pancreas/duodenum homeobox protein 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	15151993	RGD
contributes to DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10094480	RGD
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	19380737	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15001545	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	8524276	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	10094480	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10094480	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	15151993	RGD
involved in animal organ regeneration	IEP IEP: Inferred from expression pattern	17690043	RGD
involved in cell differentiation	IMP IMP: Inferred from mutant phenotype	11309388	RGD
involved in glucose mediated signaling pathway	IDA IDA: Inferred from direct assay	21108535	RGD
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17641871	RGD
involved in pancreas development	IEP IEP: Inferred from expression pattern	18778483	RGD
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	18253862	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	11158595	RGD
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	18439098	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10094480	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21108535	RGD
involved in regulation of gene expression	IMP IMP: Inferred from mutant phenotype	10802714	RGD
involved in response to L-leucine	IEP IEP: Inferred from expression pattern	19438972	RGD
involved in response to alkaloid	IEP IEP: Inferred from expression pattern	15448089	RGD
involved in response to chlorate	IEP IEP: Inferred from expression pattern	17221210	RGD
involved in response to cytokine	IEP IEP: Inferred from expression pattern	16948396	RGD
involved in response to fatty acid	IEP IEP: Inferred from expression pattern	17181874	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	15331541	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	18230696	RGD
involved in response to glucose	IMP IMP: Inferred from mutant phenotype	15148392	RGD
involved in response to iron(II) ion	IEP IEP: Inferred from expression pattern	16081762	RGD
involved in response to lipid	IEP IEP: Inferred from expression pattern	17991758	RGD
involved in response to nicotine	IEP IEP: Inferred from expression pattern	18687784	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	17882398	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	19438972	RGD
involved in response to vitamin	IEP IEP: Inferred from expression pattern	11833042	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	17991720	RGD
involved in smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	11181516	RGD
involved in stem cell differentiation	IEP IEP: Inferred from expression pattern	19382247	RGD
involved in stem cell differentiation	IMP IMP: Inferred from mutant phenotype	18253862	RGD
involved in transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15151993	RGD
involved in transdifferentiation	IEP IEP: Inferred from expression pattern	10952464	RGD
involved in type B pancreatic cell differentiation	IMP IMP: Inferred from mutant phenotype	21108535	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

pancreas/duodenum homeobox protein 1

IDX-1	IPF-1
Insulin promoter factor 1	STF-1
insulin promotor factor 1	islet/duodenum homeobox-1
pancreatic and duodenal homeobox gene 1	somatostatin transactivating factor 1

Pdx1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Pdx1	P52947	Psmd9	Rattus norvegicus	Q9WTV5	Y2H	15885879
Intra	Pdx1	P52947	Psmd9	Rattus norvegicus	Q9WTV5	Pull Down	15885879

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0777	Isorhamnetin-3-O-glucoside		99.96%	Unkown
HY-19694	BRD7552	Activator	99.32%	Unkown
HY-RS10264	PDHX Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10295	PDX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20792	Pdx1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21404	Pdhx Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27306	Pdx1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991294	MGTA-117 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pdx1	NCBI	NCBI:3651

Name
Email *

	Sorry, but the email address you supplied was invalid.