Tesk1 - testis associated actin remodelling kinase 1 Gene

Rattus norvegicus

Gene ID: 29460 | Gene type: protein coding

About Tesk1

Summary

Enables protein C-terminus binding activity; protein kinase binding activity; and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of protein phosphorylation; positive regulation of stress fiber assembly; and spermatogenesis. Located in perinuclear region of cytoplasm. Colocalizes with cytoplasmic vesicle. Orthologous to human TESK1 (testis associated actin remodelling kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Tesk1 Products(1)

mRNA	Protein	Name
NM_031578.2	NP_113766.1	dual specificity testis-specific protein kinase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11555644	RGD
enables protein kinase activity	IDA IDA: Inferred from direct assay	11555644	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	18216281	RGD
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	8537404	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of protein autophosphorylation	IDA IDA: Inferred from direct assay	18216281	RGD
involved in negative regulation of protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	18216281	RGD
involved in positive regulation of stress fiber assembly	IDA IDA: Inferred from direct assay	18216281	RGD
involved in regulation of protein localization	IDA IDA: Inferred from direct assay	18216281	RGD
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	8537404	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	22302232	RGD
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	18216281	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	22302232	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

dual specificity testis-specific protein kinase 1

testicular protein kinase 1	testis specific protein kinase 1
testis-specific kinase 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14380	TESK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22856	Tesk1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29370	Tesk1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tesk1	NCBI	NCBI:7016

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