2. Gene
  3. Mcu - mitochondrial calcium uniporter Gene

Mcu - mitochondrial calcium uniporter Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Ccdc109a

Gene ID: 294560 | Gene type: protein coding

About Mcu

Summary

Enables uniporter activity. Involved in mitochondrial calcium ion transmembrane transport and positive regulation of mitochondrial calcium ion concentration. Located in mitochondrial inner membrane. Orthologous to human MCU (mitochondrial calcium uniporter). [provided by Alliance of Genome Resources, Apr 2022]

Mcu Products(1)

mRNA Protein Name
NM_001106398.1 NP_001099868.1 calcium uniporter protein, mitochondrial precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables uniporter activity IDA
IDA: Inferred from direct assay
16920631 RGD
enables uniporter activity IMP
IMP: Inferred from mutant phenotype
22425903 RGD
Biological Process GO Annotation Evidence Reference Source
involved in mitochondrial calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
22425903 RGD
involved in mitochondrial calcium ion transmembrane transport IDA
IDA: Inferred from direct assay
16920631 RGD
involved in mitochondrial calcium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
22425903 RGD
involved in positive regulation of mitochondrial calcium ion concentration IDA
IDA: Inferred from direct assay
16920631 RGD
involved in positive regulation of mitochondrial calcium ion concentration IMP
IMP: Inferred from mutant phenotype
22425903 RGD
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
16920631 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

calcium uniporter protein, mitochondrial

coiled-coil domain containing 109A

coiled-coil domain-containing protein 109A

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-138620 MCU-i4 Inhibitor 99.87% Unkown
HY-W194810 MCU-i11 98.42% Unkown
HY-RS08252 MCU Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS16775 Mcu Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23215 Mcu Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mcu NCBI NCBI:90550