2. Gene
  3. Cfb - complement factor B Gene

Cfb - complement factor B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Bf; Da1-24

Gene ID: 294257 | Gene type: protein coding

About Cfb

Summary

Predicted to enable G protein-coupled receptor activity and serine-type endopeptidase activity. Involved in complement activation; response to lipopolysaccharide; and response to thyroid hormone. Located in extracellular space. Biomarker of polycystic kidney disease and retinal degeneration. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; autoimmune disease (multiple); eye disease (multiple); glomerulonephritis (multiple); and sickle cell anemia. Orthologous to human CFB (Complement Factor B). [provided by Alliance of Genome Resources, Apr 2022]

Cfb Products(1)

mRNA Protein Name
NM_212466.3 NP_997631.2 complement factor B precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in complement activation IDA
IDA: Inferred from direct assay
6906329 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
18023983 RGD
involved in response to thyroid hormone IMP
IMP: Inferred from mutant phenotype
22370704 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
3853462 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

complement factor B

B-factor, properdin

properdin factor B

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-148370 IONIS-FB-LRx Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148370A IONIS-FB-LRx sodium Inhibitor 93.90% Unkown
HY-RS02557 CFB Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17438 Cfb Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23894 Cfb Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cfb NCBI NCBI:629
Mus musculus Cfb NCBI NCBI:14962