2. Gene
  3. IRS2 - Irs2 insulin receptor substrate 2 Gene

IRS2 - Irs2 insulin receptor substrate 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as 4PS; IRS-2

Gene ID: 29376 | Gene type: protein coding

About IRS2

Summary

Enables several functions, including 14-3-3 protein binding activity; Insulin Receptor binding activity; and phosphatidylinositol 3-kinase binding activity. Involved in cellular response to glucose stimulus and Insulin Receptor signaling pathway. Predicted to be part of protein-containing complex. Predicted to be active in cytosol and plasma membrane. Biomarker of non-alcoholic fatty liver disease and osteoporosis. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IRS2 (Insulin Receptor substrate 2). [provided by Alliance of Genome Resources, Apr 2022]

IRS2 Products(1)

mRNA Protein Name
NM_001168633.1 NP_001162104.1 insulin receptor substrate 2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables 14-3-3 protein binding IDA
IDA: Inferred from direct assay
22912850 RGD
enables insulin receptor binding IMP
IMP: Inferred from mutant phenotype
12850498 RGD
enables phosphatidylinositol 3-kinase binding IMP
IMP: Inferred from mutant phenotype
12850498 RGD
enables phosphatidylinositol 3-kinase binding IPI
IPI: Inferred from physical interaction
12891559 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
21742014 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
12891559 RGD
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
12891559 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
16574657 RGD
involved in cellular response to insulin stimulus IDA
IDA: Inferred from direct assay
22912850 RGD
involved in cellular response to peptide IEP
IEP: Inferred from expression pattern
18406357 RGD
involved in insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12891559 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

insulin receptor substrate 2

tyrosine kinase substrate

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P0119 Lixisenatide Agonist 99.93% Unkown
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-170994 I2-IRs ligand-1 Ligand / Unkown
HY-RS06918 IRS2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-P0119S Lixisenatide (Leu-13C6,15N) TFA / Unkown
HY-RS19342 Irs2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25833 Irs2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens IRS2 NCBI NCBI:8660