Spint2 - serine peptidase inhibitor, Kunitz type, 2 Gene

Rattus norvegicus

Also known as Pb; HAI-2

Gene ID: 292770 | Gene type: protein coding

About Spint2

Summary

Predicted to enable serine-type endopeptidase inhibitor activity. Involved in cellular response to BMP stimulus and negative regulation of neural precursor cell proliferation. Located in plasma membrane. Human ortholog(s) of this gene implicated in congenital secretory sodium diarrhea 3. Orthologous to human SPINT2 (serine peptidase inhibitor, Kunitz type 2). [provided by Alliance of Genome Resources, Apr 2022]

Spint2 Products(2)

mRNA	Protein	Name
NM_001082549.1	NP_001076018.1	kunitz-type protease inhibitor 2 isoform a precursor
NM_199087.1	NP_954518.1	kunitz-type protease inhibitor 2 isoform b precursor

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to BMP stimulus	IEP IEP: Inferred from expression pattern	23409135	RGD
involved in negative regulation of neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	23409135	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

kunitz-type protease inhibitor 2

hepatocyte growth factor activator inhibitor type 2	placental bikunin
serine protease inhibitor, Kunitz type 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13686	SPINT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19530	Spint2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26025	Spint2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Spint2	NCBI	NCBI:10653
Mus musculus	Spint2	NCBI	NCBI:20733

Name
Email *

	Sorry, but the email address you supplied was invalid.