2. Gene
  3. Tnni3 - troponin I3, cardiac type Gene

Tnni3 - troponin I3, cardiac type Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as TnI; cTNI

Gene ID: 29248 | Gene type: protein coding

About Tnni3

Summary

Predicted to enable several functions, including Calcium Channel Inhibitor activity; calcium-dependent protein binding activity; and cytoskeletal protein binding activity. Involved in cardiac muscle contraction and regulation of smooth muscle contraction. Located in sarcomere. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple). Orthologous to human TNNI3 (troponin I3, cardiac type). [provided by Alliance of Genome Resources, Apr 2022]

Tnni3 Products(1)

mRNA Protein Name
NM_017144.2 NP_058840.1 troponin I, cardiac muscle
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21569246 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cardiac muscle contraction IDA
IDA: Inferred from direct assay
11448842 RGD
involved in cardiac muscle contraction IMP
IMP: Inferred from mutant phenotype
9409484 RGD
involved in regulation of smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
16236710 RGD
Cellular Component GO Annotation Evidence Reference Source
located in contractile muscle fiber IDA
IDA: Inferred from direct assay
9409484 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
15601779 RGD
located in myofibril IDA
IDA: Inferred from direct assay
11448842 RGD
located in sarcomere IDA
IDA: Inferred from direct assay
15601779 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

troponin I, cardiac muscle

cardiac troponin I

troponin 1, type 3

troponin I type 3 (cardiac)

Tnni3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Cross
Tnni3 P23693 PDE4DIP Homo sapiens Q5VU43-11
Anti Tag CoIP
21569246
Cross
Tnni3 P23693 PDE4DIP Homo sapiens Q5VU43-11
Anti Bait CoIP
21569246
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-119608 GSK854 Inhibitor 98.40% Unkown
HY-117243 GSK329 Inhibitor 99.60% Unkown
HY-117658 GSK-114 Inhibitor 99.52% Unkown
HY-RS14852 TNNI3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14853 TNNI3K Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18101 Tnni3k Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19243 Tnni3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24575 Tnni3k Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25732 Tnni3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnni3 NCBI NCBI:7137
Mus musculus Tnni3 NCBI NCBI:21954