2. Gene
  3. Hax1 - HCLS1 associated protein X-1 Gene

Hax1 - HCLS1 associated protein X-1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as HAX-1; Hs1bp1

Gene ID: 291202 | Gene type: protein coding

About Hax1

Summary

Enables protein domain specific binding activity. Predicted to be involved in several processes, including positive regulation of intracellular signal transduction; positive regulation of protein phosphorylation; and regulation of actin Cytoskeleton organization. Located in apical plasma membrane; clathrin-coated vesicle; and sarcoplasmic reticulum. Human ortholog(s) of this gene implicated in severe congenital neutropenia 3. Orthologous to human HAX1 (HCLS1 associated protein X-1). [provided by Alliance of Genome Resources, Apr 2022]

Hax1 Products(1)

mRNA Protein Name
NM_181627.2 NP_853658.1 HCLS1-associated protein X-1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15159385 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
15159385 RGD
Cellular Component GO Annotation Evidence Reference Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
15159385 RGD
located in clathrin-coated vesicle IDA
IDA: Inferred from direct assay
15159385 RGD
located in sarcoplasmic reticulum IDA
IDA: Inferred from direct assay
19920172 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

HCLS1-associated protein X-1

HS1 binding protein

HS1-associating protein X-1

HS1-binding protein 1

HSP1BP-1

Hax1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Hax1 Q7TSE9 Abcb4 Rattus norvegicus Q08201
Y2H
15159385
Intra
Hax1 Q7TSE9 Abcb11 Rattus norvegicus O70127
Pull Down
15159385
Intra
Hax1 Q7TSE9 Abcb11 Rattus norvegicus O70127
IF
15159385
Intra
Hax1 Q7TSE9 Abcb11 Rattus norvegicus O70127
Anti Bait CoIP
15159385
Intra
Hax1 Q7TSE9 Abcb11 Rattus norvegicus O70127
Y2H
15159385
Intra
Hax1 Q7TSE9 Abcb1a Rattus norvegicus Q6PSM0
Anti Bait CoIP
15159385
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06023 HAX1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS22196 Hax1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hax1 NCBI NCBI:10456