2. Gene
  3. USH2A - Ush2a usherin Gene

USH2A - Ush2a usherin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as RGD1560269

Gene ID: 289369 | Gene type: protein coding

About USH2A

Summary

Predicted to enable Collagen binding activity; identical protein binding activity; and Myosin binding activity. Involved in retina development in camera-type eye. Located in stereocilium and synapse. Colocalizes with several cellular components, including neuronal cell body; photoreceptor connecting cilium; and photoreceptor inner segment. Human ortholog(s) of this gene implicated in Usher syndrome (multiple); nonsyndromic deafness; and retinitis pigmentosa (multiple). Orthologous to human USH2A (usherin). [provided by Alliance of Genome Resources, Apr 2022]

USH2A Products(1)

mRNA Protein Name
NM_001302219.1 NP_001289148.1 usherin
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in retina development in camera-type eye IEP
IEP: Inferred from expression pattern
12160733 RGD
Cellular Component GO Annotation Evidence Reference Source
located in neuronal cell body IDA
IDA: Inferred from direct assay
16434480 RGD
located in photoreceptor connecting cilium IDA
IDA: Inferred from direct assay
16434480 RGD
located in photoreceptor inner segment IDA
IDA: Inferred from direct assay
16434480 RGD
located in stereocilium IDA
IDA: Inferred from direct assay
16301216 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
16434480 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

usherin

Usher syndrome 2A (autosomal recessive, mild) homolog

Usher syndrome 2A homolog

usher syndrome type IIa protein homolog

usher syndrome type-2A protein homolog

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-147412 Ultevursen / Phase 3
Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15518 USH2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22899 Ush2a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29413 Ush2a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens USH2A NCBI NCBI:7399