Ddx5 - DEAD-box helicase 5 Gene

Rattus norvegicus

Gene ID: 287765 | Gene type: protein coding

About Ddx5

Summary

Enables several functions, including RNA helicase activity; calcium-dependent protein binding activity; and Calmodulin binding activity. Involved in regulation of viral genome replication. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of catalytic step 2 spliceosome. Predicted to be active in nucleus. Orthologous to human DDX5 (DEAD-box helicase 5). [provided by Alliance of Genome Resources, Apr 2022]

Ddx5 Products(1)

mRNA	Protein	Name
NM_001007613.1	NP_001007614.1	probable ATP-dependent RNA helicase DDX5

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA helicase activity	IDA IDA: Inferred from direct assay	7525583	RGD
enables calcium-dependent protein binding	IDA IDA: Inferred from direct assay	7525583	RGD
enables calmodulin binding	IDA IDA: Inferred from direct assay	7525583	RGD
enables enzyme binding	IDA IDA: Inferred from direct assay	19224332	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	17960593	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of viral genome replication	IMP IMP: Inferred from mutant phenotype	19224332	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

probable ATP-dependent RNA helicase DDX5

DEAD (Asp-Glu-Ala-Asp) box helicase 5	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
ddx5 gene protein	p68 RNA helicase

Ddx5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Ddx5	Q6AYI1	a0a3g5biy8_sars	SARS coronavirus Urbani	A0A3G5BIY8	Y2H	19224332
Cross	Ddx5	Q6AYI1	a0a3g5biy8_sars	SARS coronavirus Urbani	A0A3G5BIY8	Gal4 VP16 Complement	19224332
Cross	Ddx5	Q6AYI1	a0a3g5biy8_sars	SARS coronavirus Urbani	A0A3G5BIY8	Anti Tag CoIP	19224332

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-168739	Topoisomerase I inhibitor 17		/	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12486	FL118		99.40%	Unkown
HY-160438B	PBX-7011 TFA	Inhibitor	98.60%	Unkown
HY-160438A	PBX-7011 mesylate	Inhibitor	/	Unkown
HY-160438	PBX-7011	Inhibitor	/	Unkown
HY-RS03655	DDX5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16886	Ddx5 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23328	Ddx5 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ddx5	NCBI	NCBI:1655

Name
Email *

	Sorry, but the email address you supplied was invalid.