2. Gene
  3. Sarm1 - sterile alpha and TIR motif containing 1 Gene

Sarm1 - sterile alpha and TIR motif containing 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 287545 | Gene type: protein coding

About Sarm1

Summary

Predicted to enable NAD+ nucleotidase, cyclic ADP-ribose generating and identical protein binding activity. Predicted to be involved in several processes, including NAD catabolic process; positive regulation of neuron death; and regulation of dendrite morphogenesis. Predicted to act upstream of or within regulation of apoptotic process and response to glucose. Predicted to be located in microtubule; mitochondrion; and synapse. Predicted to be extrinsic component of mitochondrial outer membrane. Predicted to be active in dendrite. Orthologous to human SARM1 (sterile alpha and TIR motif containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Sarm1 Products(1)

mRNA Protein Name
NM_001105817.1 NP_001099287.1 NAD(+) hydrolase SARM1
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in modification of postsynaptic structure IDA
IDA: Inferred from direct assay
21555464 RGD
involved in modification of postsynaptic structure IMP
IMP: Inferred from mutant phenotype
21555464 RGD
Cellular Component GO Annotation Evidence Reference Source
is active in extrinsic component of synaptic membrane IDA
IDA: Inferred from direct assay
21555464 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
21555464 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
21555464 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NAD(+) hydrolase SARM1

NADP(+) hydrolase SARM1

NADase SARM1

sterile alpha and TIR motif-containing protein 1

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0985 Phenazopyridine hydrochloride Antagonist 99.84% Unkown
HY-B0985A Phenazopyridine Antagonist 99.93% Unkown
Pre-clinical Phase
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-129522 Sulfo-ara-F-NMN Activator 99.36% Unkown
HY-W021879 DSRM-3716 Inhibitor 99.91% Unkown
HY-145917 SARM1-IN-2 Inhibitor 99.34% Unkown
HY-Z0816 Dehydronitrosonisoldipine Antagonist 98.86% Unkown
HY-161918 SARM1-IN-3 Inhibitor / Unkown
HY-172967 SARM1-IN-5 Inhibitor / Unkown
HY-173276 SARM1-IN-4 Inhibitor / Unkown
HY-176487 SARM1-IN-6 / Unkown
HY-RS12446 SARM1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS16722 Sarm1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23158 Sarm1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W008341 5-Chloroisoquinoline Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sarm1 NCBI NCBI:23098