2. Gene
  3. Nbn - nibrin Gene

Nbn - nibrin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Nbs1

Gene ID: 27354 | Gene type: protein coding

About Nbn

Summary

Enables damaged DNA binding activity. Involved in blastocyst growth and isotype switching. Acts upstream of or within cell population proliferation; intracellular signal transduction; and neuromuscular process controlling balance. Located in PML body and replication fork. Colocalizes with chromosome, telomeric region. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and respiratory system. Used to study Nijmegen breakage syndrome and T-cell acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in several diseases, including Nijmegen breakage syndrome; acute lymphoblastic leukemia; aplastic anemia; breast cancer; and reproductive organ Cancer (multiple). Orthologous to human NBN (nibrin). [provided by Alliance of Genome Resources, Apr 2022]

Nbn Products(1)

mRNA Protein Name
NM_013752.3 NP_038780.3 nibrin
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables chromatin-protein adaptor activity IDA
IDA: Inferred from direct assay
28216226 MGI
enables damaged DNA binding IDA
IDA: Inferred from direct assay
11934988 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17429352 MGI
Biological Process GO Annotation Evidence Reference Source
involved in blastocyst growth IMP
IMP: Inferred from mutant phenotype
14612522 MGI
involved in double-strand break repair via alternative nonhomologous end joining IDA
IDA: Inferred from direct assay
28216226 MGI
involved in in utero embryonic development IMP
IMP: Inferred from mutant phenotype
14612522 MGI
acts upstream of or within intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
18614044 MGI
involved in isotype switching IDA
IDA: Inferred from direct assay
15668383 MGI
acts upstream of or within mitotic G2 DNA damage checkpoint signaling IMP
IMP: Inferred from mutant phenotype
18614044 MGI
acts upstream of or within neuroblast proliferation IMP
IMP: Inferred from mutant phenotype
15821748 MGI
acts upstream of or within neuromuscular process controlling balance IMP
IMP: Inferred from mutant phenotype
15821748 MGI
involved in protection from non-homologous end joining at telomere IDA
IDA: Inferred from direct assay
28216226 MGI
involved in telomere maintenance in response to DNA damage IDA
IDA: Inferred from direct assay
28216226 MGI
Cellular Component GO Annotation Evidence Reference Source
part of Mre11 complex IDA
IDA: Inferred from direct assay
18854157 MGI
located in PML body IDA
IDA: Inferred from direct assay
23444137 MGI
colocalizes with chromosome, telomeric region IDA
IDA: Inferred from direct assay
23444137 MGI
is active in chromosome, telomeric region IDA
IDA: Inferred from direct assay
28216226 MGI
located in chromosome, telomeric region IDA
IDA: Inferred from direct assay
10811102 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11555636 MGI
located in replication fork IDA
IDA: Inferred from direct assay
11934988 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nibrin

cell cycle regulatory protein p95

nijmegen breakage syndrome protein 1 homolog

Nbn Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Nbn Q9R207 Mre11 Mus musculus Q61216
Anti Bait CoIP
17429352
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09057 NBN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-176305S Neurofilament, U-15N / Unkown
HY-RS01048 ARTN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18740 Nbn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25227 Nbn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nbn NCBI NCBI:4683