Mre11a - MRE11A homolog A, double strand break repair nuclease Gene

Mus musculus

Also known as Mre11; Mre11b

Gene ID: 17535 | Gene type: protein coding

About Mre11a

Summary

Predicted to enable identical protein binding activity; nuclease activity; and protein C-terminus binding activity. Predicted to contribute to DNA binding activity and DNA helicase activity. Acts upstream of or within several processes, including double-strand break repair; homologous chromosome pairing at meiosis; and mitotic DNA damage checkpoint signaling. Located in PML body. Colocalizes with chromosome, telomeric region. Human ortholog(s) of this gene implicated in breast carcinoma; endometrial cancer; stomach carcinoma; and urinary bladder Cancer. Orthologous to human MRE11 (MRE11 homolog, double strand break repair nuclease). [provided by Alliance of Genome Resources, Apr 2022]

Mre11a Products(11)

mRNA	Protein	Name
NM_001310728.2	NP_001297657.1	double-strand break repair protein MRE11 isoform 2
NM_001411891.1	NP_001398820.1	double-strand break repair protein MRE11 isoform 1
NM_001411892.1	NP_001398821.1	double-strand break repair protein MRE11 isoform 2
NM_001411893.1	NP_001398822.1	double-strand break repair protein MRE11 isoform 3
NM_001411894.1	NP_001398823.1	double-strand break repair protein MRE11 isoform 3
NM_001411895.1	NP_001398824.1	double-strand break repair protein MRE11 isoform 4
NM_001411896.1	NP_001398825.1	double-strand break repair protein MRE11 isoform 5
NM_001411897.1	NP_001398826.1	double-strand break repair protein MRE11 isoform 6
NM_001411898.1	NP_001398827.1	double-strand break repair protein MRE11 isoform 6
NM_001411899.1	NP_001398828.1	double-strand break repair protein MRE11 isoform 7
NM_018736.4	NP_061206.1	double-strand break repair protein MRE11 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables nuclease activity	IMP IMP: Inferred from mutant phenotype	18854157	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17429352	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA strand resection involved in replication fork processing	IMP IMP: Inferred from mutant phenotype	18854157	MGI
acts upstream of or within cell population proliferation	IMP IMP: Inferred from mutant phenotype	9224597	MGI
acts upstream of or within chromosome organization	IMP IMP: Inferred from mutant phenotype	14690604	MGI
involved in chromosome organization	IMP IMP: Inferred from mutant phenotype	18854157	MGI
acts upstream of or within double-strand break repair	IMP IMP: Inferred from mutant phenotype	17291760	MGI
involved in double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	18854157	MGI
acts upstream of or within homologous chromosome pairing at meiosis	IMP IMP: Inferred from mutant phenotype	17291760	MGI
acts upstream of or within mitotic G2 DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	14690604	MGI
acts upstream of or within mitotic intra-S DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	14690604	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of Mre11 complex	IDA IDA: Inferred from direct assay	18854157	MGI
located in PML body	IDA IDA: Inferred from direct assay	23444137	MGI
colocalizes with chromosome, telomeric region	IDA IDA: Inferred from direct assay	23444137	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12687013	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

double-strand break repair protein MRE11

MRE11 homolog 1	MRE11 homolog A
double-strand break repair protein MRE11A	meiotic recombination 11 homolog 1
meiotic recombination 11 homolog A	mmMRE11A

Mre11a Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Mre11	Q61216	Nbn	Mus musculus	Q9R207	Anti Bait CoIP	18854157

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08643	MRE11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24170	Mre11 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

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