2. Gene
  3. Mthfd1l - methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like Gene

Mthfd1l - methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Fthfsdc1; 2410004L15Rik

Gene ID: 270685 | Gene type: protein coding

About Mthfd1l

Summary

Predicted to enable ATP binding activity; formate-tetrahydrofolate Ligase activity; and protein homodimerization activity. Involved in embryonic neurocranium morphogenesis; embryonic viscerocranium morphogenesis; and neural tube closure. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study neural tube defect. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human MTHFD1L (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like). [provided by Alliance of Genome Resources, Apr 2022]

Mthfd1l Products(3)

mRNA Protein Name
NM_001170785.1 NP_001164256.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial precursor
NM_001170786.1 NP_001164257.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial precursor
NM_172308.4 NP_758512.3 monofunctional C1-tetrahydrofolate synthase, mitochondrial precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in embryonic neurocranium morphogenesis IMP
IMP: Inferred from mutant phenotype
23267094 MGI
involved in embryonic viscerocranium morphogenesis IMP
IMP: Inferred from mutant phenotype
23267094 MGI
involved in neural tube closure IMP
IMP: Inferred from mutant phenotype
23267094 MGI
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrion IDA
IDA: Inferred from direct assay
19948730 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

monofunctional C1-tetrahydrofolate synthase, mitochondrial

formyltetrahydrofolate synthetase domain containing 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08775 MTHFD1L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20214 Mthfd1l Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26720 Mthfd1l Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mthfd1l NCBI NCBI:25902