Slc7a11 - solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 Gene

Mus musculus

Also known as sut; xCT; 9930009M05Rik

Gene ID: 26570 | Gene type: protein coding

About Slc7a11

Summary

Predicted to enable L-amino acid transmembrane transporter activity. Acts upstream of or within several processes, including animal organ development; oligopeptide transmembrane transport; and regulation of cellular amino acid metabolic process. Located in apical part of cell; astrocyte projection; and brush border membrane. Is expressed in brain; meninges; and sensory organ. Used to study Hermansky-Pudlak syndrome and platelet storage pool deficiency. Orthologous to human SLC7A11 (solute carrier family 7 member 11). [provided by Alliance of Genome Resources, Apr 2022]

Slc7a11 Products(1)

mRNA	Protein	Name
NM_011990.2	NP_036120.1	cystine/glutamate transporter

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in L-cystine transport	IMP IMP: Inferred from mutant phenotype	16037214	MGI
acts upstream of or within L-glutamate import across plasma membrane	IMP IMP: Inferred from mutant phenotype	21490221	MGI
acts upstream of or within adult behavior	IDA IDA: Inferred from direct assay	29024663	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	17035536	MGI
acts upstream of or within cellular response to oxidative stress	IDA IDA: Inferred from direct assay	17035536	MGI
acts upstream of or within cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	17035536	MGI
acts upstream of or within cellular response to stress	IDA IDA: Inferred from direct assay	29024663	MGI
acts upstream of or within dipeptide import across plasma membrane	IMP IMP: Inferred from mutant phenotype	16037214	MGI
acts upstream of or within glutathione metabolic process	IMP IMP: Inferred from mutant phenotype	17200146	MGI
acts upstream of or within glutathione transmembrane transport	IDA IDA: Inferred from direct assay	17035536	MGI
acts upstream of or within intracellular glutamate homeostasis	IGI IGI: Inferred from genetic interaction	29024663	MGI
acts upstream of or within intracellular glutamate homeostasis	IMP IMP: Inferred from mutant phenotype	21191088	MGI
acts upstream of or within limb development	IMP IMP: Inferred from mutant phenotype	21490221	MGI
acts upstream of or within lung alveolus development	IMP IMP: Inferred from mutant phenotype	23085521	MGI
acts upstream of or within modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	25429150	MGI
acts upstream of or within platelet aggregation	IMP IMP: Inferred from mutant phenotype	8699821	MGI
acts upstream of or within regulation of AMPA glutamate receptor clustering	IMP IMP: Inferred from mutant phenotype	25429150	MGI
acts upstream of or within regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16037214	MGI
acts upstream of or within regulation of cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	16037214	MGI
acts upstream of or within regulation of cysteine metabolic process	IMP IMP: Inferred from mutant phenotype	17200146	MGI
acts upstream of or within regulation of glutamate metabolic process	IMP IMP: Inferred from mutant phenotype	21490221	MGI
acts upstream of or within regulation of glutathione biosynthetic process	IMP IMP: Inferred from mutant phenotype	16037214	MGI
acts upstream of or within regulation of melanin biosynthetic process	IMP IMP: Inferred from mutant phenotype	16037214	MGI
acts upstream of or within regulation of neutrophil apoptotic process	IMP IMP: Inferred from mutant phenotype	17200146	MGI
acts upstream of or within regulation of protein transport	IMP IMP: Inferred from mutant phenotype	16037214	MGI
acts upstream of or within regulation of synapse organization	IMP IMP: Inferred from mutant phenotype	25429150	MGI
acts upstream of or within response to organic cyclic compound	IMP IMP: Inferred from mutant phenotype	21191088	MGI
acts upstream of or within response to redox state	IMP IMP: Inferred from mutant phenotype	16144837	MGI
acts upstream of or within striatum development	IMP IMP: Inferred from mutant phenotype	17035536	MGI
acts upstream of or within ventricular system development	IMP IMP: Inferred from mutant phenotype	17035536	MGI
acts upstream of or within visual learning	IMP IMP: Inferred from mutant phenotype	21490221	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical part of cell	IDA IDA: Inferred from direct assay	16399997	MGI
located in astrocyte projection	IDA IDA: Inferred from direct assay	16399997	MGI
located in brush border membrane	IDA IDA: Inferred from direct assay	16399997	MGI
located in membrane	IDA IDA: Inferred from direct assay	29350434	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16399997	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cystine/glutamate transporter

amino acid transport system xc-	cysteine/glutamate transporter
sodium independent anionic amino acid transport system	solute carrier family 7 member 11

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0653A	Levobupivacaine hydrochloride		99.86%	Yes
HY-B0653	Levobupivacaine		/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-W402682	SXC2023	Inhibitor	99.83%	Phase 2

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15763	Erastin		99.76%	Unkown
HY-W451275	HG106	Activator	99.95%	Unkown
HY-149979	SLC7A11-IN-1	Inducer	97.06%	Unkown
HY-RS13325	SLC7A11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-169056	SLC7A11-IN-2		99.80%	Unkown
HY-155851	Lepadin E		/	Unkown
HY-155852	Lepadin H	Inducer	/	Unkown
HY-161075	Microtubule inhibitor 8		/	Unkown
HY-175032	ATF3-IN-1		/	Unkown
HY-176719	AKR1B1/STAT3/SLC7A11-regulator-1		/	Unkown
HY-B0653AS	Levobupivacaine-d9 hydrochloride		/	Unkown
HY-N15742	Talaroconvolutin A		/	Unkown
HY-RS16551	Slc7a11 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22984	Slc7a11 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc7a11	NCBI	NCBI:23657

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