1. Gene
  2. Nf2 - NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor Gene

Nf2 - NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor Gene

Rattus norvegicus

Also known as merlin

Gene ID: 25744 | Gene type: protein coding

About Nf2

Summary

Enables beta-catenin binding activity; Integrin binding activity; and protein domain specific binding activity. Involved in negative regulation of cell growth. Located in several cellular components, including membrane raft; perinuclear region of cytoplasm; and synapse. Part of protein-containing complex. Biomarker of epilepsy. Human ortholog(s) of this gene implicated in familial meningioma; neurilemmomatosis; and neurofibromatosis 2. Orthologous to human NF2 (NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor). [provided by Alliance of Genome Resources, Apr 2022]

Nf2 Products(1)

mRNA Protein Name
NM_013193.1 NP_037325.1 merlin
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables beta-catenin binding IPI
IPI: Inferred from physical interaction
15659388 RGD
enables integrin binding IPI
IPI: Inferred from physical interaction
9858254 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15659388 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
11316791 RGD
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of cell growth IDA
IDA: Inferred from direct assay
11316791 RGD
Cellular Component GO Annotation Evidence Reference Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
9858254 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
11316791 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

merlin

moesin-ezrin-radixin-like protein

neurofibromatosis 2

neurofibromin-2

schwannomin

Nf2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Nf2 Q63648 Amot Rattus norvegicus A0A0G2JX94 21481793
Cross: Cross-species interaction Intra: Intraspecies interaction

Orthologs Information

Species Symbol Source ID
Homo sapiens Nf2 NCBI NCBI:4771
Macaca fascicularis Nf2 NCBI NCBI:102139594
Mus musculus Nf2 NCBI NCBI:18016