Ccne1 - cyclin E1 Gene

Rattus norvegicus

Also known as Ccne; CYCLE

Gene ID: 25729 | Gene type: protein coding

About Ccne1

Summary

Enables protein kinase binding activity. Involved in several processes, including animal organ development; response to nutrient; and response to steroid hormone. Located in centrosome; cytoplasm; and nucleus. Biomarker of hepatocellular carcinoma; hypertension; and ovarian carcinoma. Human ortholog(s) of this gene implicated in breast adenocarcinoma. Orthologous to human CCNE1 (cyclin E1). [provided by Alliance of Genome Resources, Apr 2022]

Ccne1 Products(1)

mRNA	Protein	Name
NM_001100821.1	NP_001094291.1	G1/S-specific cyclin-E1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18356301	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	15809057	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	10952244	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in animal organ regeneration	IEP IEP: Inferred from expression pattern	16273211	RGD
involved in antral ovarian follicle growth	IEP IEP: Inferred from expression pattern	17084963	RGD
involved in cellular response to nutrient	IEP IEP: Inferred from expression pattern	17979132	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	15809057	RGD
involved in positive regulation of cell differentiation	IDA IDA: Inferred from direct assay	15642789	RGD
involved in response to corticosterone	IEP IEP: Inferred from expression pattern	12807724	RGD
involved in response to cytokine	IEP IEP: Inferred from expression pattern	17483238	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	16019103	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	16689928	RGD
involved in response to methylmercury	IEP IEP: Inferred from expression pattern	17056119	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	17654247	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	12810531	RGD
involved in response to purine-containing compound	IEP IEP: Inferred from expression pattern	16759516	RGD
involved in response to steroid hormone	IEP IEP: Inferred from expression pattern	16273211	RGD
involved in response to vitamin E	IEP IEP: Inferred from expression pattern	16298738	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	16760380	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	15514162	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

G1/S-specific cyclin-E1

cyclin E

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-145817A	lunresertib	Inhibitor	99.97%	Phase 2
HY-160701	Cirtociclib		99.02%	Phase 2

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-162255	CDK2-IN-23	Inhibitor	99.22%	Unkown
HY-RS02127	CCNE1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-161463	CDK2-IN-28	Inhibitor	/	Unkown
HY-RS17273	Ccne1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23727	Ccne1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ccne1	NCBI	NCBI:898
Mus musculus	Ccne1	NCBI	NCBI:12447

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