Smad1 - SMAD family member 1 Gene

Rattus norvegicus

Also known as Madh1

Gene ID: 25671 | Gene type: protein coding

About Smad1

Summary

Predicted to enable several functions, including SMAD binding activity; enzyme binding activity; and nucleic acid binding activity. Involved in several processes, including BMP signaling pathway; negative regulation of muscle cell apoptotic process; and positive regulation of dendrite morphogenesis. Located in cytoplasm and nucleus. Used to study pulmonary hypertension. Biomarker of glomerulonephritis; male infertility; nephrotic syndrome; and pulmonary hypertension. Orthologous to human SMAD1 (Smad Family member 1). [provided by Alliance of Genome Resources, Apr 2022]

Smad1 Products(2)

mRNA	Protein	Name
NM_013130.3	NP_037262.3	mothers against decapentaplegic homolog 1
NM_013130.3	NP_037262.3	mothers against decapentaplegic homolog 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12552124	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	16020542	RGD
involved in MAPK cascade	IMP IMP: Inferred from mutant phenotype	16427075	RGD
involved in cardiac muscle hypertrophy in response to stress	IMP IMP: Inferred from mutant phenotype	26873969	RGD
involved in kidney development	IEP IEP: Inferred from expression pattern	11850197	RGD
involved in negative regulation of muscle cell apoptotic process	IEP IEP: Inferred from expression pattern	11408477	RGD
involved in positive regulation of cell differentiation	IDA IDA: Inferred from direct assay	17525996	RGD
involved in positive regulation of dendrite morphogenesis	IEP IEP: Inferred from expression pattern	15056710	RGD
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	18079356	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

mothers against decapentaplegic homolog 1

MAD (mothers against decapentaplegic, Drosophila) homolog 1	MAD homolog 1
MAD homolog1 (mothers against decapentaplegic, Drosophila)	SMAD 1
SMAD, mothers against DPP homolog 1	mothers against DPP homolog 1

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-145608	Zilurgisertib	Inhibitor	99.77%	Phase 2

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99359	Elezanumab	Inhibitor	99.91%	Phase 2
HY-P99353	Ascrinvacumab	Inhibitor	97.45%	Phase 2

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124697	BMP signaling agonist sb4	Agonist	99.98%	Unkown
HY-12274	ML347	Inhibitor	99.94%	Unkown
HY-108527	CD1530		98.01%	Unkown
HY-164145	CDD-1653		99.38%	Unkown
HY-123900	AZ12799734	Inhibitor	98.07%	Unkown
HY-N0946	(-)-Pinoresinol 4-O-glucoside	Inhibitor	≥98.0%	Unkown
HY-173149	CDD-2789	Inhibitor	/	Unkown
HY-174416	Smurf1-IN-5	Inhibitor	/	Unkown
HY-RS05279	GARS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13392	SMAD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18190	Smad1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24664	Smad1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Smad1	NCBI	NCBI:4086

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