2. Gene
  3. Trh - thyrotropin releasing hormone Gene

Trh - thyrotropin releasing hormone Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as THR; Trf; TRH01; Pro-TRH

Gene ID: 25569 | Gene type: protein coding

About Trh

Summary

This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The rat proprotein contains five thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as Prolactin, and may be involved in cardiac function in heart failure. Disruption of this gene is associated with hypothyroidism, elevated thyroid-stimulating hormone levels, and hyperglycemia. [provided by RefSeq, May 2013]

Trh Products(1)

mRNA Protein Name
NM_013046.3 NP_037178.1 thyrotropin releasing hormone preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables thyrotropin-releasing hormone activity IDA
IDA: Inferred from direct assay
12369739 RGD
Biological Process GO Annotation Evidence Reference Source
involved in eating behavior IDA
IDA: Inferred from direct assay
16959836 RGD
involved in histamine metabolic process IDA
IDA: Inferred from direct assay
17760865 RGD
involved in negative regulation of feeding behavior IDA
IDA: Inferred from direct assay
17760865 RGD
involved in negative regulation of glutamate secretion IDA
IDA: Inferred from direct assay
16055093 RGD
involved in positive regulation of gamma-aminobutyric acid secretion IDA
IDA: Inferred from direct assay
16990402 RGD
involved in positive regulation of insulin secretion IDA
IDA: Inferred from direct assay
16118471 RGD
involved in response to corticosterone IEP
IEP: Inferred from expression pattern
16293347 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
15680480 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
15680480 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
15726019 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
16075386 RGD
Cellular Component GO Annotation Evidence Reference Source
located in secretory granule IDA
IDA: Inferred from direct assay
3930986 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

thyrotropin releasing hormone

TSH-releasing factor

pro-thyrotropin-releasing hormone

prothyroliberin

protirelin

thyrotropin-releasing factor

Related Agents

Approval
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0596 Taltirelin 99.91% Unkown
HY-P0002 Protirelin Activator 99.98% Unkown
HY-P0002A Protirelin acetate Activator 99.98% Yes
HY-B0596A Taltirelin acetate 98.77% Unkown
Pre-clinical Phase
Bioactive Molecules (22)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P3960 (Glu2)-TRH Inhibitor 99.68% Unkown
HY-P1213 JKC363 Antagonist 99.55% Unkown
HY-107380A PGlu-3-methyl-His-Pro-NH2 TFA 99.69% Unkown
HY-P10485 Glp-Asn-Pro-AMC 99.26% Unkown
HY-117178 TA 0910 acid-type Control 99.85% Unkown
HY-118117 Rovatirelin / Unkown
HY-15113 Y-29794 Inhibitor / Unkown
HY-15113A Y-29794 tosylate Inhibitor / Unkown
HY-19154 Montirelin / Unkown
HY-B0596S Taltirelin-13C,d3 / Unkown
HY-P1213A JKC363 TFA Antagonist / Unkown
HY-P3962 [Phe2]-TRH / Unkown
HY-P3964 TRH Precursor Peptide / Unkown
HY-P3969 Prepro-TRH-(160-169) Agonist / Unkown
HY-P4367 TRH-AMC / Unkown
HY-P4584 TRH-βNA / Unkown
HY-RS15011 TRH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W345393 Trh-gly Agonist / Unkown
HY-122353 Orotirelin / Unkown
HY-136800 Posatirelin Inhibitor / Unkown
HY-RS16699 Trh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23133 Trh Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trh NCBI NCBI:7200
Macaca fascicularis Trh NCBI NCBI:101926744