Nfkbia - NFKB inhibitor alpha Gene

Rattus norvegicus

Also known as RL/IF-1

Gene ID: 25493 | Gene type: protein coding

About Nfkbia

Summary

Enables NF-kappaB binding activity and heat shock protein binding activity. Involved in several processes, including cytoplasmic sequestering of NF-kappaB; leukocyte migration involved in inflammatory response; and liver regeneration. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in cytosol and nucleus. Part of protein-containing complex. Used to study gastritis; pulmonary emphysema; and sciatic neuropathy. Biomarker of several diseases, including acute necrotizing pancreatitis; alcoholic hepatitis; artery disease (multiple); middle cerebral artery infarction; and toxic shock syndrome. Human ortholog(s) of this gene implicated in several diseases, including childhood-onset asthma; hematologic Cancer (multiple); hepatitis B; hepatitis C; and lung disease (multiple). Orthologous to human NFKBIA (NFKB inhibitor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Nfkbia Products(1)

mRNA	Protein	Name
NM_001105720.2	NP_001099190.2	NF-kappa-B inhibitor alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NF-kappaB binding	IPI IPI: Inferred from physical interaction	16135962	RGD
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	16135962	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	12672265	RGD

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to cytokine stimulus	IDA IDA: Inferred from direct assay	19414010	RGD
acts upstream of or within cellular response to organic cyclic compound	IDA IDA: Inferred from direct assay	19414010	RGD
involved in cytoplasmic sequestering of NF-kappaB	IMP IMP: Inferred from mutant phenotype	9343439	RGD
involved in leukocyte migration involved in inflammatory response	IEP IEP: Inferred from expression pattern	27939985	RGD
involved in liver regeneration	IEP IEP: Inferred from expression pattern	24446557	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	27939985	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	27939985	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	19414010	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	16135962	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

NF-kappa-B inhibitor alpha

I-kappa-B-alpha	Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells, alpha
ikB-alpha	ikappaBalpha
nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha	nuclear factor of kappa light polypeptide gene enhan

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09260	NFKBIA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18565	Nfkbia Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25048	Nfkbia Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nfkbia	NCBI	NCBI:4792

Name
Email *

	Sorry, but the email address you supplied was invalid.