Myo9b - myosin IXb Gene

Rattus norvegicus

Gene ID: 25486 | Gene type: protein coding

About Myo9b

Summary

Enables several functions, including ATP hydrolysis activity; ATP-dependent protein binding activity; and adenyl ribonucleotide binding activity. Involved in Rho protein signal transduction. Located in several cellular components, including actin filament; lamellipodium; and ruffle. Human ortholog(s) of this gene implicated in celiac disease. Orthologous to human MYO9B (Myosin IXB). [provided by Alliance of Genome Resources, Apr 2022]

Myo9b Products(3)

mRNA	Protein	Name
NM_001271066.2	NP_001257995.1	unconventional myosin-IXb isoform 1
NM_001271067.2	NP_001257996.1	unconventional myosin-IXb isoform 2
NM_012984.4	NP_037116.2	unconventional myosin-IXb isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ADP binding	IDA IDA: Inferred from direct assay	16179355	RGD
enables ADP binding	IMP IMP: Inferred from mutant phenotype	16179355	RGD
enables ATP binding	IDA IDA: Inferred from direct assay	16179355	RGD
enables ATP binding	IMP IMP: Inferred from mutant phenotype	16179355	RGD
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	16179355	RGD
enables ATP hydrolysis activity	IMP IMP: Inferred from mutant phenotype	16179355	RGD
enables ATP-dependent protein binding	IDA IDA: Inferred from direct assay	7882973	RGD
enables GTPase activator activity	IDA IDA: Inferred from direct assay	7882973	RGD
enables GTPase activator activity	IMP IMP: Inferred from mutant phenotype	9348541	RGD
enables actin binding	IDA IDA: Inferred from direct assay	7882973	RGD
enables actin filament binding	IDA IDA: Inferred from direct assay	7882973	RGD
enables actin filament binding	IMP IMP: Inferred from mutant phenotype	16179355	RGD
enables microfilament motor activity	IDA IDA: Inferred from direct assay	16179355	RGD
enables microfilament motor activity	IMP IMP: Inferred from mutant phenotype	16179355	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15644318	RGD
enables zinc ion binding	IDA IDA: Inferred from direct assay	7882973	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in Rho protein signal transduction	IDA IDA: Inferred from direct assay	7882973	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in actin filament	IDA IDA: Inferred from direct assay	9348541	RGD
located in lamellipodium	IDA IDA: Inferred from direct assay	9348541	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	9348541	RGD
located in ruffle	IDA IDA: Inferred from direct assay	9348541	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

unconventional myosin-IXb

Unconventional myosin from rat 3	myr 5
unconventional myosin-9b

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08953	MYO9B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22665	Myo9b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29179	Myo9b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Myo9b	NCBI	NCBI:4650

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