HMGB1 - Hmgb1 high mobility group box 1 Gene

Rattus norvegicus

Also known as Hmg1; Ac2-008

Gene ID: 25459 | Gene type: protein coding

About HMGB1

Summary

Enables several functions, including DNA binding activity; heparin binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of DNA ligation; positive regulation of cytokine production; and response to bacterium. Acts upstream of or within several processes, including DNA geometric change; induction of positive chemotaxis; and positive regulation of mesenchymal cell proliferation. Located in several cellular components, including cytosol; extracellular space; and membrane raft. Used to study congestive heart failure; high grade glioma; myocardial infarction; pulmonary hypertension; and sciatic neuropathy. Biomarker of several diseases, including atherosclerosis; colon adenocarcinoma; hydrocephalus; middle cerebral artery infarction; and obstructive jaundice. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human HMGB1 (high mobility group box 1). [provided by Alliance of Genome Resources, Apr 2022]

HMGB1 Products(1)

mRNA	Protein	Name
NM_012963.3	NP_037095.1	high mobility group protein B1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 5S rRNA binding	IDA IDA: Inferred from direct assay	18845125	RGD
enables DNA binding, bending	IDA IDA: Inferred from direct assay	17964600	RGD
enables RAGE receptor binding	IMP IMP: Inferred from mutant phenotype	15644117	RGD
enables RAGE receptor binding	IPI IPI: Inferred from physical interaction	7592757	RGD
enables bent DNA binding	IDA IDA: Inferred from direct assay	10962007	RGD
enables crossed form four-way junction DNA binding	IDA IDA: Inferred from direct assay	10962007	RGD
enables cytokine activity	IDA IDA: Inferred from direct assay	14744997	RGD
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	11024186	RGD
enables four-way junction DNA binding	IDA IDA: Inferred from direct assay	1547772	RGD
enables glycolipid binding	IDA IDA: Inferred from direct assay	11279268	RGD
enables heparin binding	IDA IDA: Inferred from direct assay	11279268	RGD
enables open form four-way junction DNA binding	IDA IDA: Inferred from direct assay	10962007	RGD
enables peptide binding	IDA IDA: Inferred from direct assay	11748221	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	14581561	RGD
enables protein heterodimerization activity	EXP EXP: Inferred from Experiment	38331917	RGD
enables single-stranded DNA binding	IDA IDA: Inferred from direct assay	11024186	RGD

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within DNA geometric change	IDA IDA: Inferred from direct assay	10962007	RGD
involved in actin cytoskeleton organization	IDA IDA: Inferred from direct assay	11257120	RGD
involved in cell morphogenesis	IMP IMP: Inferred from mutant phenotype	1885601	RGD
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	16354107	RGD
involved in chemotaxis	IDA IDA: Inferred from direct assay	19139725	RGD
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	17226794	RGD
acts upstream of or within induction of positive chemotaxis	IDA IDA: Inferred from direct assay	14744997	RGD
involved in male-specific defense response to bacterium	IDA IDA: Inferred from direct assay	16997939	RGD
involved in myoblast proliferation	IMP IMP: Inferred from mutant phenotype	16407300	RGD
involved in negative regulation of DNA replication	IDA IDA: Inferred from direct assay	18191612	RGD
involved in nervous system development	IMP IMP: Inferred from mutant phenotype	1885601	RGD
involved in neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	19944723	RGD
involved in neuron projection development	IGI IGI: Inferred from genetic interaction	7592757	RGD
involved in positive regulation of DNA ligation	IDA IDA: Inferred from direct assay	10866811	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16407300	RGD
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	23604926	RGD
acts upstream of or within positive regulation of cell migration	IDA IDA: Inferred from direct assay	14744997	RGD
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	18929840	RGD
involved in positive regulation of interleukin-1 production	IDA IDA: Inferred from direct assay	10952726	RGD
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	10952726	RGD
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	22514737	RGD
involved in positive regulation of interleukin-8 production	IDA IDA: Inferred from direct assay	10952726	RGD
involved in positive regulation of macrophage inflammatory protein 1 alpha production	IDA IDA: Inferred from direct assay	10952726	RGD
acts upstream of or within positive regulation of mesenchymal cell proliferation	IDA IDA: Inferred from direct assay	14744997	RGD
acts upstream of or within positive regulation of mitotic cell cycle	IDA IDA: Inferred from direct assay	14744997	RGD
involved in positive regulation of myeloid cell apoptotic process	IDA IDA: Inferred from direct assay	18952078	RGD
involved in positive regulation of myoblast differentiation	IMP IMP: Inferred from mutant phenotype	15143181	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	11507219	RGD
involved in positive regulation of smooth muscle cell migration	IDA IDA: Inferred from direct assay	11257120	RGD
involved in positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	10952726	RGD
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	22514737	RGD
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	1547772	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	18596634	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	15192048	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	19959191	RGD
involved in response to type II interferon	IMP IMP: Inferred from mutant phenotype	18004227	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	16125245	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	14499952	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	20160670	RGD
located in membrane raft	IDA IDA: Inferred from direct assay	14499952	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

high mobility group protein B1

Ac2-008-like	HMG-1
amphoterin	heparin-binding protein p30
high mobility group 1	high mobility group protein 1

Related Agents

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0184	Glycyrrhizic acid	Inhibitor	99.84%	Yes
HY-B0581	Dexrazoxane		99.88%	Yes
HY-N0184A	Dipotassium glycyrrhizinate	Inhibitor	99.68%	Yes
HY-N0184R	Glycyrrhizic acid (Standard)	Inhibitor	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9928	Alirocumab	Inhibitor	97.00%	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-Y1362	Ethyl pyruvate		99.87%	Phase 4
HY-10447	Terameprocol		99.33%	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P9928A	Alirocumab (anti-PCSK9)	Inhibitor	98.24%	Phase 4

Pre-clinical Phase

Bioactive Molecules (29)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101872	GSK-872	Inhibitor	99.91%	Unkown
HY-111815A	N4-Acetylcytidine triphosphate sodium		99.91%	Unkown
HY-101872A	GSK-872 hydrochloride	Inhibitor	99.21%	Unkown
HY-P2268	RAGE antagonist peptide	Antagonist	98.81%	Unkown
HY-162065	N6F11	Inducer	98.37%	Unkown
HY-113772	Inflachromene	Inhibitor	99.76%	Unkown
HY-W019670	N4-Acetylcytidine		99.65%	Unkown
HY-148226	20-5,14-HEDGE		99.28%	Unkown
HY-P3042	Chymostatin	Inhibitor	≥99.0%	Unkown
HY-124750	NecroX-7	Inhibitor	99.69%	Unkown
HY-P2268A	RAGE antagonist peptide TFA	Antagonist	99.71%	Unkown
HY-N2055	Kaempferol 3-O-sophoroside		99.41%	Unkown
HY-155751	HMGB1-IN-1	Inhibitor	99.37%	Unkown
HY-163409	CGK012	Inhibitor	99.96%	Unkown
HY-111815	N4-Acetylcytidine triphosphate		/	Unkown
HY-RS06232	HMGB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-143456	Anti-inflammatory agent 18	Inhibitor	/	Unkown
HY-143457	Anti-inflammatory agent 19	Inhibitor	/	Unkown
HY-155759	HMGB1-IN-2	Inhibitor	/	Unkown
HY-168053	HMGB1-IN-3		/	Unkown
HY-168650	ROCK/HDAC-IN-1	Inhibitor	/	Unkown
HY-19421	Orazamide	Inhibitor	/	Unkown
HY-N9587	Tricin 7-O-β-D-glucopyranoside	Inducer	/	Unkown
HY-P10321	HBP08		/	Unkown
HY-W753593	N4-Acetylcytidine-13C5		/	Unkown
HY-110051	DPP4-In hydrochloride		/	Unkown
HY-RS16500	Hmgb1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22930	Hmgb1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25102	Hbp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990117	Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10)	Inhibitor	95.00%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	HMGB1	NCBI	NCBI:3146
Mus musculus	HMGB1	NCBI	NCBI:15289

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