Cyp1b1 - cytochrome P450, family 1, subfamily b, polypeptide 1 Gene

Rattus norvegicus

Gene ID: 25426 | Gene type: protein coding

About Cyp1b1

Summary

Enables monooxygenase activity. Involved in several processes, including positive regulation of macromolecule biosynthetic process; response to gonadotropin; and response to steroid hormone. Located in nucleus. Biomarker of breast adenocarcinoma and esophagus squamous cell carcinoma. Human ortholog(s) of this gene implicated in Peters anomaly; anterior segment dysgenesis 6; breast cancer; glaucoma (multiple); and lung squamous cell carcinoma. Orthologous to human CYP1B1 (Cytochrome P450 family 1 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp1b1 Products(1)

mRNA	Protein	Name
NM_012940.2	NP_037072.1	cytochrome P450 1B1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables monooxygenase activity	IDA IDA: Inferred from direct assay	15258110	RGD
enables oxidoreductase activity	IDA IDA: Inferred from direct assay	16893557	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA modification	IMP IMP: Inferred from mutant phenotype	24025706	RGD
involved in adrenal gland development	IEP IEP: Inferred from expression pattern	10098502	RGD
involved in benzene-containing compound metabolic process	IDA IDA: Inferred from direct assay	9806168	RGD
involved in benzene-containing compound metabolic process	IMP IMP: Inferred from mutant phenotype	24025706	RGD
involved in cellular response to cAMP	IEP IEP: Inferred from expression pattern	21389345	RGD
involved in cellular response to cortisol stimulus	IEP IEP: Inferred from expression pattern	8674863	RGD
involved in cellular response to luteinizing hormone stimulus	IEP IEP: Inferred from expression pattern	21389345	RGD
involved in cellular response to progesterone stimulus	IEP IEP: Inferred from expression pattern	8674863	RGD
involved in cellular response to toxic substance	IMP IMP: Inferred from mutant phenotype	31746392	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	10403529	RGD
involved in estrogen metabolic process	IDA IDA: Inferred from direct assay	23821647	RGD
involved in estrogen metabolic process	IMP IMP: Inferred from mutant phenotype	16893557	RGD
involved in estrous cycle	IEP IEP: Inferred from expression pattern	12223220	RGD
involved in ganglion development	IEP IEP: Inferred from expression pattern	17687037	RGD
involved in male gonad development	IEP IEP: Inferred from expression pattern	19074971	RGD
involved in positive regulation of DNA biosynthetic process	IMP IMP: Inferred from mutant phenotype	20439821	RGD
involved in positive regulation of apoptotic process	IEP IEP: Inferred from expression pattern	18336843	RGD
involved in positive regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	20439821	RGD
involved in positive regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	20439821	RGD
involved in positive regulation of translation	IMP IMP: Inferred from mutant phenotype	20439821	RGD
involved in response to 3-methylcholanthrene	IEP IEP: Inferred from expression pattern	19889059	RGD
involved in response to arsenic-containing substance	IEP IEP: Inferred from expression pattern	23999541	RGD
involved in response to dexamethasone	IEP IEP: Inferred from expression pattern	9804617	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	19074971	RGD
involved in response to follicle-stimulating hormone	IEP IEP: Inferred from expression pattern	19074971	RGD
involved in response to indole-3-methanol	IEP IEP: Inferred from expression pattern	11719698	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	11739881	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	7744798	RGD
involved in response to steroid hormone	IEP IEP: Inferred from expression pattern	12704664	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	7788849	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cytochrome P450 1B1

CYPIB1	P450RAP
cytochrome P450, subfamily 1B, polypeptide 1	cytochrome P450RAP
hydroperoxy icosatetraenoate dehydratase

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1234	Octinoxate		99.84%	Unkown
HY-W017113	2-Mercaptobenzothiazole	Activator	99.85%	Yes

Pre-clinical Phase

Bioactive Molecules (27)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19340	TMS	Inhibitor	99.40%	Unkown
HY-W007700	8-Bromooctanoic acid		99.89%	Unkown
HY-101284	DMU2105	Inhibitor	99.54%	Unkown
HY-152118	CYP1B1-IN-4	Inhibitor	99.09%	Unkown
HY-101285	DMU2139	Inhibitor	≥98.0%	Unkown
HY-146393	PROTAC CYP1B1 degrader-1	Inhibitor	98.09%	Unkown
HY-RS03443	CYP1B1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-157942	CYP1B1-IN-7	Inhibitor	99.88%	Unkown
HY-159006	CYP1B1 ligand 3	Inhibitor	/	Unkown
HY-150557	CYP1B1-IN-1	Inhibitor	/	Unkown
HY-150558	CYP1B1-IN-2	Inhibitor	/	Unkown
HY-152079	CYP1B1-IN-3	Inhibitor	/	Unkown
HY-152196	CYP1B1-IN-5	Inhibitor	/	Unkown
HY-158429	PROTAC CYP1B1 degrader-2	Degrader	/	Unkown
HY-158430	CYP1B1 ligand 2		/	Unkown
HY-161403	CYP1B1-IN-8	Inhibitor	/	Unkown
HY-162051	CYP1B1-IN-6	Inhibitor	/	Unkown
HY-E70476	Human CYP1B1,Low-Reductase		/	Unkown
HY-101284A	(E/Z)-DMU2105	Inhibitor	/	Unkown
HY-126308	(E/Z)-DMU2139	Inhibitor	/	Unkown
HY-158431	(S,R,S)-AHPC-Me-8-bromooctanoic acid		/	Unkown
HY-B1234S	Octinoxate-13C,d3		/	Unkown
HY-RS16945	Cyp1b1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23388	Cyp1b1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W472509	11-HETE	Activator	/	Unkown
HY-W517092	1,2,3,4,7,8,9-Heptachlorodibenzofuran		/	Unkown
HY-W775354	1,2,3,4,7,8-Hexachlorodibenzofuran		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cyp1b1	NCBI	NCBI:1545

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