VCAM1 - Vcam1 vascular cell adhesion molecule 1 Gene

Rattus norvegicus

Also known as VCAM1B

Gene ID: 25361 | Gene type: protein coding

About VCAM1

Summary

Enables Integrin binding activity. Involved in several processes, including cellular response to tumor necrosis factor; nervous system development; and response to lipopolysaccharide. Located in cell surface; extracellular space; and sarcolemma. Used to study carotid stenosis and hypertension. Biomarker of several diseases, including artery disease (multiple); chronic kidney disease; colitis; periodontitis; and thromboangiitis obliterans. Orthologous to human VCAM1 (vascular cell adhesion molecule 1). [provided by Alliance of Genome Resources, Apr 2022]

VCAM1 Products(2)

mRNA	Protein	Name
NM_012889.2	NP_037021.1	vascular cell adhesion protein 1 precursor
NM_012889.2	NP_037021.1	vascular cell adhesion protein 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables integrin binding	IMP IMP: Inferred from mutant phenotype	1377031	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cardiac neuron differentiation	IMP IMP: Inferred from mutant phenotype	12486170	RGD
involved in cell adhesion	IMP IMP: Inferred from mutant phenotype	1377031	RGD
involved in cell chemotaxis	IMP IMP: Inferred from mutant phenotype	23226762	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	15980038	RGD
involved in cellular response to vascular endothelial growth factor stimulus	IEP IEP: Inferred from expression pattern	23226762	RGD
involved in chronic inflammatory response	IEP IEP: Inferred from expression pattern	10706728	RGD
involved in innervation	IMP IMP: Inferred from mutant phenotype	12486170	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	22521742	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	19465514	RGD
involved in response to ionizing radiation	IEP IEP: Inferred from expression pattern	19714308	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	22433071	RGD
involved in response to nicotine	IEP IEP: Inferred from expression pattern	22218593	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	19199090	RGD
involved in response to zinc ion	IEP IEP: Inferred from expression pattern	20128680	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	11870719	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	22521742	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	11870719	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

vascular cell adhesion protein 1

V-CAM 1	VCAM-1
vascular cell adhesion protein 1-like

Related Agents

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108831	Natalizumab	Antagonist	≥99.10%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-121705	Propionyl-L-carnitine		≥95.0%	Phase 3

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-108831A	Natalizumab (Solution)	Antagonist	98.72%	Phase 4

Pre-clinical Phase

Bioactive Molecules (18)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0602	Ginsenoside Rg2	Inhibitor	98.11%	Unkown
HY-N1353	Rhamnocitrin	Inhibitor	99.67%	Unkown
HY-N1990	Gypenoside XLIX	Activator	99.88%	Unkown
HY-112868B	ABH hydrochloride		99.83%	Unkown
HY-N2110	Phellopterin		99.94%	Unkown
HY-N0617	Sanggenon C		98.46%	Unkown
HY-W588250	Surfactin C1	Antagonist	99.36%	Unkown
HY-14921	Elsibucol	Inhibitor	99.35%	Unkown
HY-143243	Antioxidant agent-5	Inhibitor	/	Unkown
HY-159179	α4 integrin receptor antagonist 3	Inhibitor	/	Unkown
HY-163712S	17-Epiestriol-d5-1		/	Unkown
HY-170916	Angiogenesis inhibitor 7	Inhibitor	/	Unkown
HY-N0602R	Ginsenoside Rg2 (Standard)	Inhibitor	/	Unkown
HY-N10047	7,8-Didehydrocimigenol	Inhibitor	/	Unkown
HY-RS15618	VCAM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-163712	17-Epiestriol	Agonist	/	Unkown
HY-RS17114	Vcam1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23559	Vcam1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990294	Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7)	Inhibitor	95.00%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	VCAM1	NCBI	NCBI:7412
Macaca fascicularis	VCAM1	NCBI	NCBI:102131307

Name
Email *

	Sorry, but the email address you supplied was invalid.