2. Gene
  3. Tnfrsf11b - TNF receptor superfamily member 11B Gene

Tnfrsf11b - TNF receptor superfamily member 11B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Opg

Gene ID: 25341 | Gene type: protein coding

About Tnfrsf11b

Summary

Predicted to enable cytokine activity. Involved in several processes, including negative regulation of bone resorption; negative regulation of odontogenesis of dentin-containing tooth; and response to estrogen. Located in extracellular space. Biomarker of congestive heart failure; myocarditis; and periapical periodontitis. Human ortholog(s) of this gene implicated in Paget's disease of bone and osteoarthritis. Orthologous to human TNFRSF11B (TNF Receptor Superfamily member 11b). [provided by Alliance of Genome Resources, Apr 2022]

Tnfrsf11b Products(1)

mRNA Protein Name
NM_012870.2 NP_037002.1 tumor necrosis factor receptor superfamily member 11B precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of bone resorption IDA
IDA: Inferred from direct assay
16912914 RGD
involved in negative regulation of bone resorption IMP
IMP: Inferred from mutant phenotype
11839361 RGD
involved in negative regulation of odontogenesis of dentin-containing tooth IEP
IEP: Inferred from expression pattern
16283633 RGD
involved in response to arsenic-containing substance IEP
IEP: Inferred from expression pattern
17190191 RGD
involved in response to estrogen IEP
IEP: Inferred from expression pattern
16624776 RGD
involved in response to magnesium ion IEP
IEP: Inferred from expression pattern
16162295 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
16696921 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
16696922 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
22353912 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 11B

Osteoprotegerin

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14802 TNFRSF11B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17571 Tnfrsf11b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24031 Tnfrsf11b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnfrsf11b NCBI NCBI:4982
Mus musculus Tnfrsf11b NCBI NCBI:18383
Macaca mulatta Tnfrsf11b NCBI NCBI:701850