Bmp4 - bone morphogenetic protein 4 Gene

Rattus norvegicus

Also known as BOMPR4A

Gene ID: 25296 | Gene type: protein coding

About Bmp4

Summary

Enables growth factor activity and identical protein binding activity. Involved in several processes, including animal organ development; positive regulation of calcium ion transport; and positive regulation of cell differentiation. Acts upstream of or within positive regulation of ossification and positive regulation of transcription by RNA polymerase II. Located in cytoplasm; extracellular space; and vesicle. Biomarker of Barrett's esophagus; congenital diaphragmatic hernia; epilepsy; peptic esophagitis; and prolactinoma. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and otosclerosis. Orthologous to human BMP4 (bone morphogenetic protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Bmp4 Products(1)

mRNA	Protein	Name
NM_012827.2	NP_036959.2	bone morphogenetic protein 4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables growth factor activity	IDA IDA: Inferred from direct assay	12475223	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	16245174	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in anatomical structure regression	IEP IEP: Inferred from expression pattern	12808102	RGD
involved in cardiac muscle hypertrophy in response to stress	IMP IMP: Inferred from mutant phenotype	26873969	RGD
involved in cellular response to BMP stimulus	IEP IEP: Inferred from expression pattern	9246083	RGD
involved in cellular response to dexamethasone stimulus	IDA IDA: Inferred from direct assay	17537984	RGD
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	20877159	RGD
involved in cellular response to oxidative stress	IDA IDA: Inferred from direct assay	22710965	RGD
involved in cellular response to thyroid hormone stimulus	IEP IEP: Inferred from expression pattern	12395077	RGD
involved in epithelial tube branching involved in lung morphogenesis	IEP IEP: Inferred from expression pattern	8769111	RGD
involved in lung lobe development	IEP IEP: Inferred from expression pattern	15991191	RGD
involved in negative regulation of oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	16388796	RGD
involved in ovarian follicle development	IMP IMP: Inferred from mutant phenotype	12801979	RGD
involved in positive regulation of bone mineralization	IDA IDA: Inferred from direct assay	15352071	RGD
involved in positive regulation of branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	17537984	RGD
involved in positive regulation of calcium ion transport into cytosol	IMP IMP: Inferred from mutant phenotype	20844246	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17286956	RGD
involved in positive regulation of endothelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	12808102	RGD
involved in positive regulation of hepatocyte differentiation	IMP IMP: Inferred from mutant phenotype	19229878	RGD
involved in positive regulation of mesenchymal stem cell proliferation	IMP IMP: Inferred from mutant phenotype	19723531	RGD
involved in positive regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	19287192	RGD
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	23325243	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	23325243	RGD
acts upstream of or within positive regulation of ossification	IDA IDA: Inferred from direct assay	7911662	RGD
involved in positive regulation of ossification	IMP IMP: Inferred from mutant phenotype	17112416	RGD
involved in positive regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	16245174	RGD
involved in positive regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	17112416	RGD
involved in positive regulation of store-operated calcium channel activity	IMP IMP: Inferred from mutant phenotype	20844246	RGD
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7911662	RGD
involved in regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	19229878	RGD
involved in regulation of cell differentiation	IDA IDA: Inferred from direct assay	12514223	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	16551644	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	17537984	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	10404008	RGD
involved in response to nitric oxide	IEP IEP: Inferred from expression pattern	15991191	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	12730624	RGD
involved in response to retinoic acid	IEP IEP: Inferred from expression pattern	8385738	RGD
involved in response to testosterone	IEP IEP: Inferred from expression pattern	20660069	RGD
involved in retina development in camera-type eye	IEP IEP: Inferred from expression pattern	17069773	RGD
involved in tongue morphogenesis	IEP IEP: Inferred from expression pattern	16828469	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	18758911	RGD
located in vesicle	IDA IDA: Inferred from direct assay	18758911	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

bone morphogenetic protein 4

BMP-2B	BMP-4
bone morphogenetic protein 2B

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124697	BMP signaling agonist sb4	Agonist	99.98%	Unkown
HY-16712	LDN-214117	Inhibitor	99.92%	Unkown
HY-18961	PD 407824	Inhibitor	99.00%	Unkown
HY-147372	SJ000063181	Agonist	98.92%	Unkown
HY-P10710	BMP-4	Inhibitor	/	Unkown
HY-RS01539	BMP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16511	Bmp4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22943	Bmp4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bmp4	NCBI	NCBI:652
Mus musculus	Bmp4	NCBI	NCBI:12159

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