2. Gene
  3. Gdf5 - growth differentiation factor 5 Gene

Gdf5 - growth differentiation factor 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Cdmp1

Gene ID: 252835 | Gene type: protein coding

About Gdf5

Summary

Enables signaling receptor binding activity. Involved in several processes, including negative regulation of neuron apoptotic process; ossification involved in bone remodeling; and positive regulation of neuron differentiation. Predicted to be active in extracellular space. Biomarker of Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease and bone disease (multiple). Orthologous to human GDF5 (Growth Differentiation Factor 5). [provided by Alliance of Genome Resources, Apr 2022]

Gdf5 Products(1)

mRNA Protein Name
NM_001398661.1 NP_001385590.1 growth differentiation factor 5 preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables signaling receptor binding IMP
IMP: Inferred from mutant phenotype
15906156 RGD
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
15906156 RGD
involved in ossification involved in bone remodeling IEP
IEP: Inferred from expression pattern
10404008 RGD
involved in positive regulation of neuron differentiation IDA
IDA: Inferred from direct assay
15906156 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
10404008 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

growth differentiation factor 5

growth/differentiation factor 5

cartilage-derived morphogenetic protein 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05355 GDF5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18243 Gdf5 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24722 Gdf5 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gdf5 NCBI NCBI:8200