Gclc - glutamate-cysteine ligase, catalytic subunit Gene

Rattus norvegicus

Also known as Glclc

Gene ID: 25283 | Gene type: protein coding

About Gclc

Summary

Enables glutamate-cysteine Ligase activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to hormone stimulus; and cellular response to mechanical stimulus. Part of glutamate-cysteine Ligase complex. Used to study liver cirrhosis and pulmonary emphysema. Human ortholog(s) of this gene implicated in cystic fibrosis; glutamate-cysteine Ligase deficiency; hemolytic anemia; and myocardial infarction. Orthologous to human GCLC (glutamate-cysteine Ligase catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]

Gclc Products(1)

mRNA	Protein	Name
NM_012815.2	NP_036947.1	glutamate--cysteine ligase catalytic subunit

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables glutamate-cysteine ligase activity	IDA IDA: Inferred from direct assay	12425961	RGD
enables glutamate-cysteine ligase activity	IMP IMP: Inferred from mutant phenotype	16183645	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	16137247	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to fibroblast growth factor stimulus	IEP IEP: Inferred from expression pattern	18042181	RGD
involved in cellular response to follicle-stimulating hormone stimulus	IEP IEP: Inferred from expression pattern	18042181	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	20466058	RGD
involved in cellular response to hepatocyte growth factor stimulus	IEP IEP: Inferred from expression pattern	20466058	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	15169830	RGD
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	20054150	RGD
involved in cellular response to thyroxine stimulus	IEP IEP: Inferred from expression pattern	17291985	RGD
involved in glutathione biosynthetic process	IMP IMP: Inferred from mutant phenotype	16183645	RGD
involved in negative regulation of hepatic stellate cell activation	IMP IMP: Inferred from mutant phenotype	22942279	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	16183645	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	20018823	RGD
involved in response to cadmium ion	IEP IEP: Inferred from expression pattern	10702364	RGD
involved in response to human chorionic gonadotropin	IEP IEP: Inferred from expression pattern	15811874	RGD
involved in response to interleukin-1	IEP IEP: Inferred from expression pattern	15485876	RGD
involved in response to nitrosative stress	IMP IMP: Inferred from mutant phenotype	16183645	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	22906634	RGD
involved in response to oxidative stress	IMP IMP: Inferred from mutant phenotype	16183645	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of glutamate-cysteine ligase complex	IDA IDA: Inferred from direct assay	16137247	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glutamate--cysteine ligase catalytic subunit

GCS heavy chain	Glutamylcysteine gamma synthetase light chain
gamma-ECS	gamma-glutamylcysteine synthetase

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05333	GCLC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W015600	2-Acetamidophenol		99.61%	Unkown
HY-147517	Keap1-Nrf2-IN-9	Inhibitor	98.52%	Unkown
HY-RS17688	Gclc Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24150	Gclc Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gclc	NCBI	NCBI:2729

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