Id1 - inhibitor of DNA binding 1 Gene

Rattus norvegicus

Also known as Idb1; ID125A

Gene ID: 25261 | Gene type: protein coding

About Id1

Summary

Enables several functions, including identical protein binding activity; Proteasome binding activity; and protein C-terminus binding activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to organonitrogen compound; and nervous system development. Located in centrosome and nucleus. Used to study pulmonary hypertension. Biomarker of cholestasis. Orthologous to human ID1 (inhibitor of DNA binding 1, HLH protein). [provided by Alliance of Genome Resources, Apr 2022]

Id1 Products(2)

mRNA	Protein	Name
NM_012797.2	NP_036929.2	DNA-binding protein inhibitor ID-1
NM_012797.2	NP_036929.2	DNA-binding protein inhibitor ID-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	8106493	RGD
enables proteasome binding	IPI IPI: Inferred from physical interaction	23831032	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	19167333	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell-abiotic substrate adhesion	IEP IEP: Inferred from expression pattern	11600477	RGD
involved in cellular response to dopamine	IEP IEP: Inferred from expression pattern	20600660	RGD
involved in cellular response to epidermal growth factor stimulus	IEP IEP: Inferred from expression pattern	7623812	RGD
involved in cellular response to nerve growth factor stimulus	IEP IEP: Inferred from expression pattern	7623812	RGD
involved in cellular response to peptide	IEP IEP: Inferred from expression pattern	16706836	RGD
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	16628634	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	19137015	RGD
involved in negative regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	19167333	RGD
involved in negative regulation of endothelial cell differentiation	IMP IMP: Inferred from mutant phenotype	20830586	RGD
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23831032	RGD
involved in neuron differentiation	IEP IEP: Inferred from expression pattern	7908517	RGD
involved in positive regulation of actin filament bundle assembly	IMP IMP: Inferred from mutant phenotype	16628634	RGD
involved in positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	23335245	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23335245	RGD
involved in regulation of vasculature development	IMP IMP: Inferred from mutant phenotype	21472453	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	20600660	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	19167333	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

DNA-binding protein inhibitor ID-1

Inhibitor of DNA binding 1 helix-loop-helix protein (splice varaiation)	Inhibitor of DNA binding 1, helix-loop-helix protein (splice variation)
inhibitor of DNA binding 1, HLH protein	inhibitor of DNA binding 1, dominant negative helix-loop-helix prote

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124697	BMP signaling agonist sb4	Agonist	99.98%	Unkown
HY-129241	AGX51	Antagonist	99.33%	Unkown
HY-80012	SJB3-019A	Inhibitor	99.88%	Unkown
HY-110245	DMH2	Inducer	99.6%	Unkown
HY-RS06522	ID1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16689	Id1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23124	Id1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Id1	NCBI	NCBI:3397
Mus musculus	Id1	NCBI	NCBI:15901
Macaca mulatta	Id1	NCBI	NCBI:713160

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