Id1 - inhibitor of DNA binding 1, HLH protein Gene

Mus musculus

Also known as Idb1; bHLHb24; D2Wsu140e

Gene ID: 15901 | Gene type: protein coding

About Id1

Summary

Enables protein self-association and transcription regulator inhibitor activity. Involved in negative regulation of cold-induced thermogenesis; negative regulation of transcription, DNA-templated; and positive regulation of gene expression. Acts upstream of or within several processes, including endothelial cell morphogenesis; lung development; and negative regulation of macromolecule metabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human ID1 (inhibitor of DNA binding 1, HLH protein). [provided by Alliance of Genome Resources, Apr 2022]

Id1 Products(3)

mRNA	Protein	Name
NM_001355113.1	NP_001342042.1	DNA-binding protein inhibitor ID-1 isoform 1
NM_001369018.1	NP_001355947.1	DNA-binding protein inhibitor ID-1 isoform 3
NM_010495.3	NP_034625.1	DNA-binding protein inhibitor ID-1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	1922066	MGI
enables transcription regulator inhibitor activity	IDA IDA: Inferred from direct assay	17681138	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within BMP signaling pathway	IDA IDA: Inferred from direct assay	15820682	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	17717145	MGI
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	19217292	MGI
acts upstream of or within collagen metabolic process	IMP IMP: Inferred from mutant phenotype	17717145	MGI
acts upstream of endothelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	17717145	MGI
acts upstream of or within endothelial cell morphogenesis	IMP IMP: Inferred from mutant phenotype	17717145	MGI
acts upstream of or within heart development	IGI IGI: Inferred from genetic interaction	15472070	MGI
acts upstream of or within lung morphogenesis	IMP IMP: Inferred from mutant phenotype	17717145	MGI
acts upstream of or within lung vasculature development	IMP IMP: Inferred from mutant phenotype	17717145	MGI
acts upstream of or within negative regulation of DNA binding	IDA IDA: Inferred from direct assay	1922066	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	19217292	MGI
involved in negative regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	28270523	MGI
acts upstream of or within negative regulation of endothelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	17717145	MGI
acts upstream of or within negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20231428	MGI
acts upstream of or within negative regulation of osteoblast differentiation	IGI IGI: Inferred from genetic interaction	15161906	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12498716	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	19217292	MGI
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	17681138	MGI
involved in positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	17681138	MGI
acts upstream of or within protein destabilization	IDA IDA: Inferred from direct assay	15322112	MGI
acts upstream of or within protein destabilization	IGI IGI: Inferred from genetic interaction	15322112	MGI
acts upstream of or within regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	17717145	MGI
acts upstream of or within regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	12498716	MGI
acts upstream of or within response to antibiotic	IMP IMP: Inferred from mutant phenotype	17717145	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9418957	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15322112	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

DNA-binding protein inhibitor ID-1

inhibitor of differentiation 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124697	BMP signaling agonist sb4	Agonist	99.98%	Unkown
HY-129241	AGX51	Antagonist	99.33%	Unkown
HY-80012	SJB3-019A	Inhibitor	99.88%	Unkown
HY-110245	DMH2	Inducer	99.6%	Unkown
HY-RS06522	ID1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16689	Id1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23124	Id1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Id1	NCBI	NCBI:3397
Rattus norvegicus	Id1	NCBI	NCBI:25261
Macaca mulatta	Id1	NCBI	NCBI:713160

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