Aqp1 - aquaporin 1 Gene

Rattus norvegicus

Also known as CHIP28

Gene ID: 25240 | Gene type: protein coding

About Aqp1

Summary

Enables glycerol transmembrane transporter activity and water channel activity. Involved in several processes, including glycerol transport; lateral ventricle development; and positive regulation of lamellipodium assembly. Located in several cellular components, including basolateral plasma membrane; brush border; and neuronal cell body membrane. Biomarker of artery disease (multiple); autosomal recessive polycystic kidney disease; brain disease (multiple); diabetes mellitus; and uveitis. Orthologous to human AQP1 (Aquaporin 1 (Colton blood group)). [provided by Alliance of Genome Resources, Apr 2022]

Aqp1 Products(1)

mRNA	Protein	Name
NM_012778.2	NP_036910.1	aquaporin-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables glycerol transmembrane transporter activity	IDA IDA: Inferred from direct assay	7491270	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16354160	RGD
enables water channel activity	IMP IMP: Inferred from mutant phenotype	11804854	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in glycerol transmembrane transport	IDA IDA: Inferred from direct assay	7491270	RGD
involved in hyperosmotic response	IEP IEP: Inferred from expression pattern	19776169	RGD
involved in lateral ventricle development	IEP IEP: Inferred from expression pattern	16133142	RGD
involved in metanephric proximal tubule development	IEP IEP: Inferred from expression pattern	30645697	RGD
involved in positive regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	19539607	RGD
involved in positive regulation of lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	19539607	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	19351613	RGD
involved in response to hormone	IEP IEP: Inferred from expression pattern	18248364	RGD
involved in water transport	IMP IMP: Inferred from mutant phenotype	11804854	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	16133142	RGD
located in axon terminus	IDA IDA: Inferred from direct assay	17553469	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	11804854	RGD
located in brush border	IDA IDA: Inferred from direct assay	16133142	RGD
located in neuronal cell body membrane	IDA IDA: Inferred from direct assay	16309835	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	7491270	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

aquaporin-1

AQP-1	Aquaporin 1 (aquaporin channel forming integral protein 28 (CHIP))
aquaporin 1 (Colton blood group)	aquaporin-CHIP
water channel protein for red blood cells and kidney proximal tubule

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N6016	Bacopaside II		98.69%	Unkown
HY-110200	TC AQP1 1	Inhibitor	98.51%	Unkown
HY-N2013	Aristolactam I		99.31%	Unkown
HY-174166	AqF026	Inhibitor	/	Unkown
HY-RS00871	AQP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17735	Aqp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24200	Aqp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Aqp1	NCBI	NCBI:358

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