2. Gene
  3. Cdkn2b - cyclin-dependent kinase inhibitor 2B Gene

Cdkn2b - cyclin-dependent kinase inhibitor 2B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as p15

Gene ID: 25164 | Gene type: protein coding

About Cdkn2b

Summary

Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity and protein kinase binding activity. Involved in several processes, including cellular response to transforming growth factor beta stimulus; negative regulation of cell cycle G1/S phase transition; and negative regulation of glial cell proliferation. Located in nucleus. Used to study endometrial Cancer and renal cell carcinoma. Human ortholog(s) of this gene implicated in carcinoma (multiple); erythema infectiosum; hematologic Cancer (multiple); open-angle glaucoma; and urinary bladder Cancer. Orthologous to human CDKN2B (cyclin dependent kinase inhibitor 2B). [provided by Alliance of Genome Resources, Apr 2022]

Cdkn2b Products(1)

mRNA Protein Name
NM_130812.4 NP_570825.1 cyclin-dependent kinase 4 inhibitor B
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
11369440 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
11042273 RGD
involved in negative regulation of cell cycle G1/S phase transition IMP
IMP: Inferred from mutant phenotype
26526028 RGD
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
7546221 RGD
involved in negative regulation of glial cell proliferation IMP
IMP: Inferred from mutant phenotype
26526028 RGD
involved in positive regulation of epithelial cell differentiation IEP
IEP: Inferred from expression pattern
17158884 RGD
involved in response to cytokine IEP
IEP: Inferred from expression pattern
15333329 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
11513834 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cyclin-dependent kinase 4 inhibitor B

Cyclin dependent kinase inhibitor 2B (p15, inhibits CDK4)

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

p14-INK4b

p15-INK4b

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02416 CDKN2B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS21103 Cdkn2b Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27622 Cdkn2b Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdkn2b NCBI NCBI:1030