Ncl - nucleolin Gene

Rattus norvegicus

Gene ID: 25135 | Gene type: protein coding

About Ncl

Summary

Enables several functions, including ErbB-4 class receptor binding activity; laminin binding activity; and nucleic acid binding activity. Involved in several processes, including cellular response to lipopolysaccharide; liver regeneration; and positive regulation of cytokine production. Located in cell surface; cytoplasm; and nucleolus. Orthologous to human NCL (nucleolin). [provided by Alliance of Genome Resources, Apr 2022]

Ncl Products(1)

mRNA	Protein	Name
NM_012749.2	NP_036881.2	nucleolin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ErbB-4 class receptor binding	IPI IPI: Inferred from physical interaction	18523588	RGD
enables RNA binding	IDA IDA: Inferred from direct assay	2049089	RGD
enables calcium ion binding	IDA IDA: Inferred from direct assay	11948683	RGD
enables histone binding	IDA IDA: Inferred from direct assay	8424749	RGD
enables laminin binding	IDA IDA: Inferred from direct assay	8583499	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16854843	RGD
enables rRNA primary transcript binding	IDA IDA: Inferred from direct assay	3790520	RGD
enables selenocysteine insertion sequence binding	IDA IDA: Inferred from direct assay	20385601	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	6311246	RGD
enables signaling receptor binding	IDA IDA: Inferred from direct assay	18523588	RGD
enables single-stranded DNA binding	IDA IDA: Inferred from direct assay	6311246	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	21309751	RGD
involved in endocytosis	IMP IMP: Inferred from mutant phenotype	21309751	RGD
involved in liver regeneration	IEP IEP: Inferred from expression pattern	7490256	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	20050922	RGD
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	21309751	RGD
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	21309751	RGD
involved in regulation of rRNA processing	IDA IDA: Inferred from direct assay	2049089	RGD
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	19570216	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	23912744	RGD
located in dense fibrillar component	IDA IDA: Inferred from direct assay	6206987	RGD
located in fibrillar center	IDA IDA: Inferred from direct assay	6206987	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nucleolin

nucleolin-like protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-174346	Skp2-IN-4		/	Unkown
HY-12645	NCL1	Inhibitor	/	Unkown
HY-178048	Neuroprotective agent 13	Activator	/	Unkown
HY-178052	Neuroprotective agent 14	Activator	/	Unkown
HY-RS03886	DNAJC5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09086	NCL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P5551	TLN-58	Inhibitor	/	Unkown
HY-RS17936	Ncl Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24407	Ncl Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ncl	NCBI	NCBI:4691
Macaca mulatta	Ncl	NCBI	NCBI:720965

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