Neuroprotective agent 14 

Neuroprotective agent 14 is a brain-penetrant 1H-benzo[d]imidazoles compound with neuroprotective effect. Neuroprotective agent 14 can activate autophagy and clear SCMAS accumulation from iPSC-derived neural progenitor cells. Neuroprotective agent 14 can be used for the research of neurological disease, such as neuronal ceroid lipofuscinoses (NCLs)^[1].

Neuroprotective agent 14 (Compound 38b) (10 μM, 24 h) enhances the viability of pluripotent stem cell (iPSC)-derived neural progenitor cells (NPCs) with CLN3, with a maximum protective effect of 73.68 %^[1].
Neuroprotective agent 14 (10 μM, 24 h) clears the abnormal accumulation of subunit c of mitochondrial ATP synthase (SCMAS) in iPSC-NPC cells with CLN3^[1].
Neuroprotective agent 14 (10 μM, 24 h) activates the autophagic pathway in iPSC-NPC cells with CLN3^[1].
Neuroprotective agent 14 (1-10 μM) does not activate Kv7.2/7.3 voltage-gated potassium channels^[1].
Neuroprotective agent 14 shows potential to cross the blood-brain barrier with 96.25% binding in mouse brain homogenate^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Neuroprotective agent 14 (Compound 38b) (1 mg/kg for i.v., 10 mg/kg for p.o.) shows high brain penetration, with the brain/plasma concentration ratio of 3.2 and 4.5 in Balb/c mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

306.28

C₁₆H₁₃F₃N₂O

3086460-57-0

CC1=NC2=C(C=C(C=C2)OCC3=CC=C(C=C3)C(F)(F)F)N1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Simeon P, et al. Discovery of Functionalized 1H-Benzo[d]imidazoles That Confer Protective Effects in a Phenotypic CLN3 Disease Patient-Derived iPSC Model. J Med Chem. 2025 Sep 11;68(17):18530-18552.  [Content Brief]