2. Gene
  3. Chrm4 - cholinergic receptor, muscarinic 4 Gene

Chrm4 - cholinergic receptor, muscarinic 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as M4

Gene ID: 25111 | Gene type: protein coding

About Chrm4

Summary

Enables guanyl-nucleotide exchange factor activity. Involved in response to organic substance. Located in several cellular components, including axon terminus; neuronal cell body; and postsynaptic density. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane and integral component of presynaptic membrane. Colocalizes with sarcolemma. Biomarker of congestive heart failure. Orthologous to human CHRM4 (cholinergic receptor muscarinic 4). [provided by Alliance of Genome Resources, Apr 2022]

Chrm4 Products(1)

mRNA Protein Name
NM_031547.1 NP_113735.1 muscarinic acetylcholine receptor M4
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
12048193 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12048193 RGD
Cellular Component GO Annotation Evidence Reference Source
located in asymmetric synapse IDA
IDA: Inferred from direct assay
8182478 RGD
located in axon terminus IDA
IDA: Inferred from direct assay
8182478 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
8182478 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
12048193 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
8182478 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
8182478 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
15961389 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

muscarinic acetylcholine receptor M4

cholinergic receptor, muscarin 4

Chrm4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Chrm4 P08485 Camk2a Rattus norvegicus P11275
Pull Down
20461055
Intra
Chrm4 P08485 Camk2a Rattus norvegicus P11275
Enzymatic Study
20461055
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02663 CHRM4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22438 Chrm4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28961 Chrm4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chrm4 NCBI NCBI:1132