Foxa1 - forkhead box A1 Gene

Rattus norvegicus

Also known as Hnf3a

Gene ID: 25098 | Gene type: protein coding

About Foxa1

Summary

Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Orthologous to human FOXA1 (forkhead box A1). [provided by Alliance of Genome Resources, Apr 2022]

Foxa1 Products(1)

mRNA	Protein	Name
NM_012742.2	NP_036874.2	hepatocyte nuclear factor 3-alpha

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10024498	RGD
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	17220277	RGD
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	17220277	RGD
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	10024498	RGD
enables protein domain specific binding	IDA IDA: Inferred from direct assay	18003659	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	2227418	RGD

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	17220277	RGD
involved in positive regulation of hydrogen peroxide-mediated programmed cell death	IMP IMP: Inferred from mutant phenotype	19649697	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10024498	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

hepatocyte nuclear factor 3-alpha

HNF-3-alpha	HNF-3A
forkhead box protein A1

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-156190A	NR2F2-IN-1 free base	Inhibitor	99.34%	Unkown
HY-168534	WX-02-23		99.88%	Unkown
HY-RS05036	FOXA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-156190	NR2F2-IN-1	Inhibitor	/	Unkown
HY-RS17339	Foxa1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23794	Foxa1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Foxa1	NCBI	NCBI:3169

Name
Email *

	Sorry, but the email address you supplied was invalid.