Apoa1 - apolipoprotein A1 Gene

Rattus norvegicus

Also known as apoA-I

Gene ID: 25081 | Gene type: protein coding

About Apoa1

Summary

Enables amyloid-beta binding activity; Cholesterol transfer activity; and Lipase Inhibitor activity. Involved in several processes, including lipid transport; peripheral nervous system axon regeneration; and response to estrogen. Located in cell surface; extracellular space; and nucleus. Part of discoidal high-density lipoprotein particle; intermediate-density lipoprotein particle; and low-density lipoprotein particle. Used to study arteriosclerosis and hyperthyroidism. Biomarker of several diseases, including fatty liver disease (multiple); hypertension; major depressive disorder; ocular hypertension; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); familial visceral amyloidosis; hypolipoproteinemia (multiple); non-alcoholic steatohepatitis; and systemic lupus erythematosus. Orthologous to human APOA1 (Apolipoprotein A1). [provided by Alliance of Genome Resources, Apr 2022]

Apoa1 Products(1)

mRNA	Protein	Name
NM_012738.2	NP_036870.1	apolipoprotein A-I preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables amyloid-beta binding	IPI IPI: Inferred from physical interaction	9211985	RGD
enables cholesterol transfer activity	IDA IDA: Inferred from direct assay	1537840	RGD
enables lipase inhibitor activity	IDA IDA: Inferred from direct assay	10419291	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	18391222	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in animal organ regeneration	IDA IDA: Inferred from direct assay	2123716	RGD
involved in cholesterol transport	IDA IDA: Inferred from direct assay	1537840	RGD
involved in negative regulation of lipase activity	IDA IDA: Inferred from direct assay	10419291	RGD
involved in peripheral nervous system axon regeneration	IEP IEP: Inferred from expression pattern	2120218	RGD
involved in phospholipid transport	IDA IDA: Inferred from direct assay	11773045	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	2504861	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	2504861	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	7556148	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	2493483	RGD
part of discoidal high-density lipoprotein particle	IDA IDA: Inferred from direct assay	2493483	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	2579677	RGD
part of high-density lipoprotein particle	IDA IDA: Inferred from direct assay	9211985	RGD
part of intermediate-density lipoprotein particle	IDA IDA: Inferred from direct assay	9211985	RGD
part of low-density lipoprotein particle	IDA IDA: Inferred from direct assay	9211985	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

apolipoprotein A-I

apo-AI	apolipoprotein A-1
preproapolipoprotein A-I

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124187	Pinolenic acid ethyl ester		≥98.0%	Unkown
HY-13031	GW 841819X		/	Unkown
HY-165061	5(Z),11(Z),14(Z)-Eicosatrienoic acid	Inhibitor	/	Unkown
HY-RS00829	APOA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17077	Apoa1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23521	Apoa1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Apoa1	NCBI	NCBI:335
Mus musculus	Apoa1	NCBI	NCBI:11806

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