Lamp2 - lysosomal-associated membrane protein 2 Gene

Rattus norvegicus

Gene ID: 24944 | Gene type: protein coding

About Lamp2

Summary

Predicted to enable enzyme binding activity and protein domain specific binding activity. Involved in chaperone-mediated Autophagy. Acts upstream of or within protein targeting to lysosome involved in chaperone-mediated Autophagy. Located in endosome; lysosomal matrix; and lysosomal membrane. Colocalizes with membrane raft. Used to study Danon disease; cholestasis; chronic conjunctivitis; cognitive disorder; and hypertrophic cardiomyopathy. Biomarker of myocardial infarction and sciatic neuropathy. Human ortholog(s) of this gene implicated in Danon disease and hypertrophic cardiomyopathy. Orthologous to human LAMP2 (lysosomal associated membrane protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Lamp2 Products(1)

mRNA	Protein	Name
NM_017068.3	NP_058764.3	lysosome-associated membrane glycoprotein 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12505983	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in chaperone-mediated autophagy	IDA IDA: Inferred from direct assay	11082038	RGD
acts upstream of or within protein targeting to lysosome involved in chaperone-mediated autophagy	IGI IGI: Inferred from genetic interaction	18644871	RGD
acts upstream of or within protein targeting to lysosome involved in chaperone-mediated autophagy	IMP IMP: Inferred from mutant phenotype	18644871	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in endosome	IDA IDA: Inferred from direct assay	16085051	RGD
located in lysosomal matrix	IDA IDA: Inferred from direct assay	18644871	RGD
located in lysosomal membrane	IDA IDA: Inferred from direct assay	8662539	RGD
located in membrane raft	IMP IMP: Inferred from mutant phenotype	20797626	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

lysosome-associated membrane glycoprotein 2

CD107 antigen-like family member B	LAMP-2
LGP-110	LGP-96
LGP-B	lysosomal membrane glycoprotein 2
lysosomal membrane glycoprotein type B	lysosome-associated membrane protein 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-134923	CA77.1	Inducer	99.98%	Unkown
HY-112483	QX77	Inducer	99.48%	Unkown
HY-RS07510	LAMP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17112	Lamp2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23557	Lamp2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lamp2	NCBI	NCBI:3920
Macaca fascicularis	Lamp2	NCBI	NCBI:102119735
Mus musculus	Lamp2	NCBI	NCBI:16784

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