Ptn - pleiotrophin Gene

Rattus norvegicus

Also known as HARP; Hbnf

Gene ID: 24924 | Gene type: protein coding

About Ptn

Summary

Enables several functions, including glycosaminoglycan binding activity; growth factor activity; and syndecan binding activity. Involved in several processes, including animal organ development; nervous system development; and regulation of epithelial cell proliferation. Located in several cellular components, including basement membrane; neuromuscular junction; and perinuclear region of cytoplasm. Is active in postsynapse and presynapse. Used to study Parkinson's disease. Biomarker of several diseases, including extrahepatic cholestasis; liver cirrhosis; sciatic neuropathy; transient cerebral ischemia; and visual epilepsy. Human ortholog(s) of this gene implicated in adrenal carcinoma. Orthologous to human PTN (pleiotrophin). [provided by Alliance of Genome Resources, Apr 2022]

Ptn Products(1)

mRNA	Protein	Name
NM_017066.3	NP_058762.1	pleiotrophin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chondroitin sulfate proteoglycan binding	IPI IPI: Inferred from physical interaction	20369290	RGD
enables glycosaminoglycan binding	IDA IDA: Inferred from direct assay	7925491	RGD
enables growth factor activity	IDA IDA: Inferred from direct assay	16226713	RGD
enables heparan sulfate binding	IPI IPI: Inferred from physical interaction	8567685	RGD
enables heparin binding	IDA IDA: Inferred from direct assay	16226713	RGD
enables heparin binding	IPI IPI: Inferred from physical interaction	8567685	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	8175719	RGD
enables proteoglycan binding	IPI IPI: Inferred from physical interaction	8702927	RGD
enables syndecan binding	IPI IPI: Inferred from physical interaction	9817766	RGD
enables vascular endothelial growth factor binding	IPI IPI: Inferred from physical interaction	17881084	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to UV	IEP IEP: Inferred from expression pattern	17925408	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	16226713	RGD
involved in cellular response to organic cyclic compound	IEP IEP: Inferred from expression pattern	12057922	RGD
involved in cellular response to platelet-derived growth factor stimulus	IEP IEP: Inferred from expression pattern	16226713	RGD
involved in cellular response to vitamin D	IEP IEP: Inferred from expression pattern	21153232	RGD
involved in cerebellum development	IEP IEP: Inferred from expression pattern	8653419	RGD
involved in dendrite regeneration	IDA IDA: Inferred from direct assay	27671118	RGD
involved in endothelial cell differentiation	IEP IEP: Inferred from expression pattern	20830586	RGD
involved in estrous cycle	IEP IEP: Inferred from expression pattern	9846168	RGD
involved in heart development	IEP IEP: Inferred from expression pattern	17925408	RGD
involved in hindbrain development	IEP IEP: Inferred from expression pattern	9749725	RGD
involved in learning	IEP IEP: Inferred from expression pattern	24069387	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	12057922	RGD
involved in long-term synaptic potentiation	IEP IEP: Inferred from expression pattern	8904779	RGD
involved in lung development	IEP IEP: Inferred from expression pattern	2270483	RGD
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	17881084	RGD
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	17881084	RGD
involved in negative regulation of epithelial cell proliferation	IDA IDA: Inferred from direct assay	8812110	RGD
involved in negative regulation of glial cell proliferation	IMP IMP: Inferred from mutant phenotype	17881084	RGD
involved in negative regulation of membrane potential	IDA IDA: Inferred from direct assay	9753126	RGD
involved in negative regulation of mesenchymal cell proliferation	IDA IDA: Inferred from direct assay	8812110	RGD
involved in negative regulation of neuromuscular junction development	IDA IDA: Inferred from direct assay	7722643	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17925408	RGD
involved in positive regulation of axon regeneration	IDA IDA: Inferred from direct assay	27671118	RGD
involved in positive regulation of cell-substrate adhesion	IDA IDA: Inferred from direct assay	7925491	RGD
involved in positive regulation of hepatocyte proliferation	IDA IDA: Inferred from direct assay	16226713	RGD
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	7955315	RGD
involved in positive regulation of ossification	IMP IMP: Inferred from mutant phenotype	9817766	RGD
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering	IDA IDA: Inferred from direct assay	7722643	RGD
involved in regulation of cell shape	IMP IMP: Inferred from mutant phenotype	17881084	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	21688311	RGD
involved in response to ciliary neurotrophic factor	IEP IEP: Inferred from expression pattern	16914133	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	9846168	RGD
involved in response to kainic acid	IEP IEP: Inferred from expression pattern	7477935	RGD
involved in response to nerve growth factor	IEP IEP: Inferred from expression pattern	16914133	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	9846168	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	7970205	RGD
involved in retina development in camera-type eye	IEP IEP: Inferred from expression pattern	8453763	RGD
involved in retinal rod cell differentiation	IMP IMP: Inferred from mutant phenotype	16914133	RGD
involved in rod bipolar cell differentiation	IEP IEP: Inferred from expression pattern	16914133	RGD
involved in spinal cord development	IEP IEP: Inferred from expression pattern	8453763	RGD
involved in thalamus development	IEP IEP: Inferred from expression pattern	10051750	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in basement membrane	IDA IDA: Inferred from direct assay	9990431	RGD
located in cell surface	IDA IDA: Inferred from direct assay	8812110	RGD
located in extracellular region	IDA IDA: Inferred from direct assay	12057922	RGD
located in neuromuscular junction	IDA IDA: Inferred from direct assay	8812110	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16226713	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	7955321	RGD
is active in presynapse	IDA IDA: Inferred from direct assay	7955321	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

pleiotrophin

HB-GAM	HBBM
HBGF-8	OSF-1
Pleiotrophin (Heparine binding factor, Hbnf, in the mouse)	heparin affine regulatory peptide
heparin binding factor	heparin-binding brain mitogen
heparin-binding growth factor 8	heparin-binding growth-associated molecule

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11407	PTN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17103	Ptn Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23547	Ptn Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptn	NCBI	NCBI:5764
Mus musculus	Ptn	NCBI	NCBI:19242

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