2. Gene
  3. UCP1 - Ucp1 uncoupling protein 1 Gene

UCP1 - Ucp1 uncoupling protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Ucp; Ucpa; Uncp

Gene ID: 24860 | Gene type: protein coding

About UCP1

Summary

Enables GDP binding activity; GTP binding activity; and Oxidative Phosphorylation uncoupler activity. Involved in several processes, including cellular response to hormone stimulus; cellular response to lipid; and proton transmembrane transport. Located in mitochondrion. Biomarker of prediabetes syndrome. Human ortholog(s) of this gene implicated in hypertension and type 2 diabetes mellitus. Orthologous to human UCP1 (uncoupling protein 1). [provided by Alliance of Genome Resources, Apr 2022]

UCP1 Products(1)

mRNA Protein Name
NM_012682.2 NP_036814.1 mitochondrial brown fat uncoupling protein 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables GDP binding IDA
IDA: Inferred from direct assay
22952235 RGD
enables GTP binding IDA
IDA: Inferred from direct assay
12479871 RGD
enables oxidative phosphorylation uncoupler activity IDA
IDA: Inferred from direct assay
16451125 RGD
enables transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
12479871 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to dehydroepiandrosterone IEP
IEP: Inferred from expression pattern
12659879 RGD
involved in cellular response to fatty acid IDA
IDA: Inferred from direct assay
22952235 RGD
involved in cellular response to hormone stimulus IEP
IEP: Inferred from expression pattern
18079609 RGD
involved in mitochondrial transmembrane transport IDA
IDA: Inferred from direct assay
22952235 RGD
involved in mitochondrial transport IDA
IDA: Inferred from direct assay
16814247 RGD
involved in proton transmembrane transport IDA
IDA: Inferred from direct assay
16814247 RGD
involved in proton transmembrane transport IMP
IMP: Inferred from mutant phenotype
12479871 RGD
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrion IDA
IDA: Inferred from direct assay
22952235 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitochondrial brown fat uncoupling protein 1

UCP 1

mitochondrial brown fat uncoupling protein 1-like

solute carrier family 25 member 7

thermogenin

uncoupling protein 1 (mitochondrial, proton carrier)

Related Agents

Pre-clinical Phase
Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-107574 TC-E 5003 98.03% Unkown
HY-N0704 Agrimol B 99.75% Unkown
HY-110148 WWL113 Inhibitor 99.72% Unkown
HY-153813 Z16078526 Modulator 98.13% Unkown
HY-133095 BML-260 Activator 99.65% Unkown
HY-135115 Oleuropein Aglycone Inhibitor 98.46% Unkown
HY-129692 Withanone Inhibitor 93.28% Unkown
HY-148973 ZW290 Inhibitor 99.60% Unkown
HY-RS16955 Ucp1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-176148 ZGL-18 / Unkown
HY-RS15410 UCP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-153812 AST 7062601 / Unkown
HY-RS23398 Ucp1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens UCP1 NCBI NCBI:7350