Tsc2 - TSC complex subunit 2 Gene

Rattus norvegicus

Also known as Rc

Gene ID: 24855 | Gene type: protein coding

About Tsc2

Summary

Enables GTPase activator activity and protein N-terminus binding activity. Involved in several processes, including negative regulation of cell population proliferation; negative regulation of signal transduction; and regulation of neuron projection development. Acts upstream of or within cell projection organization and negative regulation of cell size. Located in several cellular components, including caveola; growth cone; and neuronal cell body. Part of protein-containing complex. Is active in glutamatergic synapse. Used to study autism spectrum disorder; hepatic angiomyolipoma; and renal cell carcinoma. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in hepatic angiomyolipoma; lymphangioleiomyomatosis; medulloblastoma; tuberous sclerosis; and tuberous sclerosis 2. Orthologous to human TSC2 (TSC complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Tsc2 Products(1)

mRNA	Protein	Name
NM_012680.3	NP_036812.2	tuberin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activator activity	IDA IDA: Inferred from direct assay	12869586	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9045618	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	15093748	RGD

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cell projection organization	IGI IGI: Inferred from genetic interaction	16286931	RGD
acts upstream of or within cell projection organization	IMP IMP: Inferred from mutant phenotype	16286931	RGD
involved in establishment of cell polarity	IMP IMP: Inferred from mutant phenotype	20530489	RGD
involved in negative regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	14612383	RGD
involved in negative regulation of TOR signaling	IDA IDA: Inferred from direct assay	12869586	RGD
involved in negative regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	12511557	RGD
involved in negative regulation of axonogenesis	IMP IMP: Inferred from mutant phenotype	18794346	RGD
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17376623	RGD
acts upstream of or within negative regulation of cell size	IMP IMP: Inferred from mutant phenotype	16286931	RGD
involved in negative regulation of epithelial cell proliferation	IDA IDA: Inferred from direct assay	14612383	RGD
involved in negative regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	20813961	RGD
involved in negative regulation of fibroblast proliferation	IDA IDA: Inferred from direct assay	18056446	RGD
involved in negative regulation of macroautophagy	IMP IMP: Inferred from mutant phenotype	24599401	RGD
involved in negative regulation of pinocytosis	IMP IMP: Inferred from mutant phenotype	9045618	RGD
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	18056446	RGD
involved in negative regulation of vascular endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	11553313	RGD
involved in positive regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	20813961	RGD
involved in positive regulation of dendritic spine development	IMP IMP: Inferred from mutant phenotype	16595860	RGD
involved in positive regulation of fibroblast migration	IMP IMP: Inferred from mutant phenotype	20530489	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	17376623	RGD
involved in protein localization to cell surface	IMP IMP: Inferred from mutant phenotype	20813961	RGD
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	24889507	RGD
involved in regulation of postsynapse organization	IMP IMP: Inferred from mutant phenotype	24889507	RGD
involved in social behavior	IMP IMP: Inferred from mutant phenotype	20927644	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in caveola	IDA IDA: Inferred from direct assay	15093748	RGD
located in cell projection	IDA IDA: Inferred from direct assay	17376623	RGD
located in dendrite	IDA IDA: Inferred from direct assay	15525761	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	24889507	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	24889507	RGD
located in growth cone	IDA IDA: Inferred from direct assay	14559897	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	15525761	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	14559897	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tuberin

renal carcinoma	tuberous sclerosis 2 homolog protein
tuberous sclerosis 2 protein homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-134904	RMC-6272	Inhibitor	95.54%	Unkown
HY-150229	306-N16B		99.27%	Unkown
HY-134922	NS1-IN-1	Inhibitor	/	Unkown
HY-RS15132	TSC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-155475	mTORC1-IN-2	Inhibitor	/	Unkown
HY-RS17096	Tsc2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23540	Tsc2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tsc2	NCBI	NCBI:7249
Mus musculus	Tsc2	NCBI	NCBI:22084

Name
Email *

	Sorry, but the email address you supplied was invalid.