Vamp2 - vesicle-associated membrane protein 2 Gene

Rattus norvegicus

Also known as SYB; Syb2; RATVAMPB; RATVAMPIR

Gene ID: 24803 | Gene type: protein coding

About Vamp2

Summary

Enables several functions, including protein C-terminus binding activity; syntaxin-1 binding activity; and transmembrane transporter binding activity. Involved in several processes, including SNARE complex assembly; exocytosis; and regulation of delayed rectifier Potassium Channel activity. Located in neuron projection terminus; plasma membrane; and secretory vesicle. Part of synaptobrevin 2-SNAP-25-syntaxin-1a complex; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; and synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex. Is integral component of synaptic vesicle membrane. Orthologous to human VAMP2 (vesicle associated membrane protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Vamp2 Products(1)

mRNA	Protein	Name
NM_012663.2	NP_036795.1	vesicle-associated membrane protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SNARE binding	IDA IDA: Inferred from direct assay	7553862	RGD
enables SNARE binding	IPI IPI: Inferred from physical interaction	9671503	RGD
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	12526776	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	21856303	RGD
enables lipid binding	EXP EXP: Inferred from Experiment	19918058	RGD
enables molecular adaptor activity	EXP EXP: Inferred from Experiment	19918058	RGD
enables myosin binding	IPI IPI: Inferred from physical interaction	16030255	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	8567678	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	8567678	RGD
enables syntaxin-1 binding	IDA IDA: Inferred from direct assay	7553862	RGD
enables syntaxin-1 binding	IPI IPI: Inferred from physical interaction	16030255	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	19077057	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in SNARE complex assembly	IMP IMP: Inferred from mutant phenotype	9671503	RGD
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	10051443	RGD
involved in regulation of delayed rectifier potassium channel activity	IDA IDA: Inferred from direct assay	19690160	RGD
involved in regulation of exocytosis	IMP IMP: Inferred from mutant phenotype	11245593	RGD
involved in regulation of synaptic vesicle recycling	IMP IMP: Inferred from mutant phenotype	21808019	RGD
involved in response to glucose	IDA IDA: Inferred from direct assay	15537656	RGD
involved in synaptic vesicle exocytosis	IDA IDA: Inferred from direct assay	1331807	RGD
involved in synaptic vesicle exocytosis	IEP IEP: Inferred from expression pattern	1331807	RGD
involved in synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	1331807	RGD
involved in vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	11245593	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of SNARE complex	IDA IDA: Inferred from direct assay	10051443	RGD
located in neuron projection terminus	IDA IDA: Inferred from direct assay	10908612	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	15537656	RGD
is active in postsynaptic cytosol	IDA IDA: Inferred from direct assay	26488171	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	26488171	RGD
located in secretory granule	IDA IDA: Inferred from direct assay	15537656	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	10908612	RGD
is active in synaptic vesicle membrane	EXP EXP: Inferred from Experiment	17110340	RGD
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	17110340	RGD
located in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	23792689	RGD
part of synaptobrevin 2-SNAP-25-syntaxin-1a complex	IDA IDA: Inferred from direct assay	7553862	RGD
part of synaptobrevin 2-SNAP-25-syntaxin-1a complex	IMP IMP: Inferred from mutant phenotype	9671503	RGD
part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex	IDA IDA: Inferred from direct assay	7553862	RGD
part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex	IDA IDA: Inferred from direct assay	19132534	RGD
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	19077057	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

vesicle-associated membrane protein 2

Synaptobrevin 2 (vesicle-associated membrane protein VAMP-2)	VAMP-2
Vesicle-associated membrane protein (synaptobrevin 2)	synaptobrevin-2

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10809	VAMP	Inhibitor	/	Unkown
HY-RS15594	VAMP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21080	Vamp2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27597	Vamp2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Vamp2	NCBI	NCBI:6844

Name
Email *

	Sorry, but the email address you supplied was invalid.