Sod2 - superoxide dismutase 2 Gene

Rattus norvegicus

Also known as MnSOD

Gene ID: 24787 | Gene type: protein coding

About Sod2

Summary

Enables several functions, including identical protein binding activity; manganese ion binding activity; and superoxide dismutase activity. Involved in several processes, including hydrogen peroxide biosynthetic process; negative regulation of membrane hyperpolarization; and positive regulation of hydrogen peroxide biosynthetic process. Located in mitochondrial nucleoid. Used to study esophagus adenocarcinoma; hypertension; intestinal disease; and myocardial infarction. Biomarker of several diseases, including adult respiratory distress syndrome; artery disease (multiple); bladder neck obstruction; congenital diaphragmatic hernia; and hyperhomocysteinemia. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); lipid storage disease (multiple); liver disease (multiple); and optic nerve disease (multiple). Orthologous to human SOD2 (superoxide dismutase 2). [provided by Alliance of Genome Resources, Apr 2022]

Sod2 Products(1)

mRNA	Protein	Name
NM_017051.2	NP_058747.1	superoxide dismutase [Mn], mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	19228881	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	24505357	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	19384983	RGD
enables manganese ion binding	IDA IDA: Inferred from direct assay	19384983	RGD
enables oxygen binding	IDA IDA: Inferred from direct assay	12107766	RGD
enables superoxide dismutase activity	IDA IDA: Inferred from direct assay	12107766	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to ethanol	IEP IEP: Inferred from expression pattern	19703426	RGD
involved in hydrogen peroxide biosynthetic process	IDA IDA: Inferred from direct assay	15642720	RGD
involved in hydrogen peroxide metabolic process	IMP IMP: Inferred from mutant phenotype	16716903	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	11961082	RGD
involved in negative regulation of membrane hyperpolarization	IMP IMP: Inferred from mutant phenotype	20529999	RGD
involved in positive regulation of hydrogen peroxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	20529999	RGD
involved in removal of superoxide radicals	IDA IDA: Inferred from direct assay	12107766	RGD
involved in response to L-ascorbic acid	IEP IEP: Inferred from expression pattern	20122981	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	19297546	RGD
involved in response to cadmium ion	IEP IEP: Inferred from expression pattern	20107868	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	17962976	RGD
involved in response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	19917063	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	16911942	RGD
involved in response to immobilization stress	IEP IEP: Inferred from expression pattern	20020182	RGD
involved in response to isolation stress	IEP IEP: Inferred from expression pattern	20020182	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	17804075	RGD
involved in response to magnetism	IEP IEP: Inferred from expression pattern	20037191	RGD
involved in response to manganese ion	IEP IEP: Inferred from expression pattern	17920449	RGD
involved in response to nutrient levels	IDA IDA: Inferred from direct assay	12067840	RGD
involved in response to oxidative stress	IEP IEP: Inferred from expression pattern	15485085	RGD
involved in response to selenium ion	IEP IEP: Inferred from expression pattern	17804075	RGD
involved in response to silicon dioxide	IEP IEP: Inferred from expression pattern	17575405	RGD
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	15959853	RGD
involved in response to zinc ion	IEP IEP: Inferred from expression pattern	20128680	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial nucleoid	IDA IDA: Inferred from direct assay	19228881	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

superoxide dismutase [Mn], mitochondrial

Superoxide dimutase 2, mitochondrial	manganese superoxide dismutase
mitochondrial superoxide dismutase 2	superoxide dismutase 2, mitochondrial

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-134476	NF-κΒ activator 1	Activator	99.59%	Unkown
HY-134477	NF-κΒ activator 2	Activator	99.76%	Unkown
HY-W014940	Ethylene glycol dimethacrylate		99.52%	Unkown
HY-158162	SIRT3 activator 1	Activator	/	Unkown
HY-RS13560	SOD2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16939	Sod2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23382	Sod2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sod2	NCBI	NCBI:6648

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